Glioblastoma Multiforme (GBM) Glioblastoma multiforme (GBM) is considered the most malignant of primary brain cancers with only about 12% of patients living beyond 36 months (long-term survivors).1,2 GBM is heterogeneous in cellular composition consisting of tumor stem cells, mesenchymal cells, and host stromal cells.3-6 In addition to the neoplastic cell populations, tumorassociated macrophage...

We initiate a theoretical investigation of the popular block-cipher design-goal of security against “related-key attacks” (RKAs). We begin by introducing definitions for the concepts of PRPs and PRFs secure against classes of RKAs, each such class being specified by an associated set of “related-key deriving (RKD) functions.” Then for some such classes of attacks, we prove impossibility results...

In this paper, we present RKD-SLAM, a robust keyframe-based dense SLAM approach for an RGB-D camera that can robustly handle fast motion and dense loop closure, and run without time limitation in a moderate size scene. It not only can be used to scan high-quality 3D models, but also can satisfy the demand of VR and AR applications. First, we combine color and depth information to construct a ve...

The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune taking immunosuppressive therapies—are to take increased precautions and avoid any unnecessary contacts. The aim of the DeCOmPRESS study define course immune profile COVID-19 in immunosupp...

PURPOSE OF THE REVIEW Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder affecting nearly all organs, including the kidney. Tubulointerstitial nephritis (IgG4-TIN) is the most common form of IgG4-related kidney disease (IgG4-RKD) and is the focus of this concise review. OBJECTIVE The study aims to describe when IgG4-TIN should be suspected and to summarize th...

UNLABELLED The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, an RNA-guided nuclease for specific genome editing in vivo, has been adopted in a wide variety of organisms. In contrast, the in vitro application of the CRISPR/Cas9 system has rarely been reported. We present here a highly efficient in vitro CRISPR/Cas9-mediated editing (...

Brassica napus seed is a lipid storage organ containing approximately 40% oil, while its leaves contain many kinds of lipids for many biological roles, but the overall amounts are less than in seeds. Thus, lipid biosynthesis in the developing seeds and the leaves is strictly regulated which results the final difference of lipids. However, there are few reports about the molecular mechanism cont...

A new drug has demonstrated some success in tackling deadly prion diseases. But, it turns out that it only treats experimentally developed, mouse-specific strains—and it may have a much darker side to it. Prion diseases—sneaky killers that always get the job done, stripping their victims of dignity, as well as of mental and physical capabilities—have been in the crosshairs of neuroscientific en...