This report describes a case of accidental intravenous administration of codeine phosphate (1 mg.kg-1) to a previously healthy five-year-old boy, who was undergoing strabismus surgery. Hypoxaemia (SpO2 85% with FIO2 of 1) and hypotension (systolic BP 65 mmHg) resulted, which responded to resuscitation with lactated Ringers' (20 ml.kg-1) and phenylephrine (2 micrograms.kg-1). The degree of hypox...

BACKGROUND The peptide drug Moli1901 activates an alternative chloride channel that is present in cystic fibrosis (CF) nasal and airway epithelia. Doing so bypasses the dysfunctional CF transmembrane regulator. STUDY OBJECTIVE To determine whether intranasal Moli1901 is safe, tolerable, and will induce chloride transport in healthy volunteers and CF subjects. DESIGN A single-blind (to the p...

Background: The World Health Organization (WHO) rehydration management guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have never been formally evaluated in a clinical trial. A recent audit of outcome of AGE at Kilifi County Hospital, Kenya noted that 10% of children required high dependency care (20% m...

dyslipidemia has become a common problem in human immunodeficiency virus (hiv) disease, especially in patients on combination antiretroviral therapy. we investigated the prevalence of and factors associated with dyslipidemia in hiv-infected patients in iran. in this cross-sectional study, 190 hiv positive patients who referring to behavioral disease consulting centers (shemiranat, varamin) and ...

Previous studies indicate that Long-Evans rats can be operantly trained to discriminate inspired CO(2) concentrations as low as 0.5%. This ability has been proposed to be due to the presence of CO(2)-sensitive olfactory receptors that contain the enzyme carbonic anhydrase (CA). The objectives of the present study were as follows: 1) to determine whether Zucker rats could be operantly conditione...

abstract: this research was done to determine the effect of using l-carnitine and selected exercises on aerobic capacity and blood lactate. in this study 30 unathletes students of shahid rajaee university took part with the age of 22/63±1/75, height: 176 cm, weight 71/33±1 and bmi: 23/17±2/6. subjects randomly divided into 3 groups, control group who were doing the selected exercises, experimen...

conclusions amateur motocross riders had significant anaerobic metabolism demands and had reduced handgrip strength following a training session. these data suggest an importance of physical training aimed at improving anaerobic and neuromuscular performance of the upper limbs in amateur motocross riders. background motocross is one of the most popular motorized off-road sports, characterized b...