A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.

conclusions our results show the presence of clonal groups of enterotoxin-producing mrsa strains in this hospital in tehran. the presence of bacteriophage encoded virulence factors and resistance to oxacillin enable bacteria to produce a broad spectrum range of diseases. results out of the 279 s. aureus isolates, 91 (32.6%) strains were confirmed as mrsa. totally, 6 enterotoxin and 2 virulence ...

background: methicillin resistant staphylococcus aureus (mrsa) nasal carriers play role in development of nosocomial infections and may increase treatment costs and mortality rate. these isolates, in addition to beta lactamase, is resistant to other drugs. carrier frequency and spectrum awareness of drug sensitivity in these isolates will be useful in choosing more effective methods of control ...

conclusions as a result of the full range uv-vis scanning of the responsible band in the hptlc experiments (200-700 nm), the flavonoid was the most imaginable natural compound. results through the bioassay guided fractionation method, the greatest antibacterial activities were related to the n-hexane extract. it was also revealed that the effective anti-mrsa agent of the assessed plant was a re...

background one of the most common nasocomial bacteria is methicillin resistant staphylococcus aureus (mrsa). today, herbal extracts like zataria multiflora from the lamiaceae family are increasingly used. objectives in this study, the antibacterial effect of z. multiflora on 75 strains of was evaluated. materials and methods the strains of staphylococcus aureus were examined for isolation of st...

background methicillin-resistant staphylococcus aureus (mrsa) is considered a major cause of nosocomial and community infections. its prevalence varies from country to country, even between hospitals of a country. these bacteria often have multi-resistance and can be difficult to treat. objectives the current study evaluated the effect of hydroalcoholic extract of the stem bark of juglans regia...

bacteremia continues to result in significant morbidity and mortality, particularly among neonates. there is scarce data on neonatal bacteremia in among iranian neonates. in this study, we determined neonatal bacteremia isolates and their antibiotic resistance pattern in neonatal insensitive care unit at beasat hospital, sanandaj, iran. during one year, all neonates admitted to the nicu were ev...

results electron microscopy showed mrsa phages’ resemblance to members of the family siphoviridae, serogroups a and f. they exhibited a latent period of 70 minutes and a relatively burst size of 2,400 plaque-forming units (pfu)/infected cell. the titer of the phages was determined to be 3 × 109 pfu/ml using the by dla technique. conclusions in this study, two phages from the family siphoviridae...

methods in a cross-sectional study, 164 adult patients who were admitted to the icu of a teaching hospital were screened for nasal and extra-nasal carriage of mrsa. in addition, the icu-hospitalized patients were evaluated for mrsa acquisition during their icu stay. results out of the 164 patients admitted to the icu, 12 (7.3%) patients were methicillin-susceptible staphylococcus aureus (mssa) ...

results of total 60 s. aureus isolates, 51 (85%) were mrsa, and of 60 cons, 7 (11.66%) were mrcons. the results showed that the mic of chlorhexidine for all 120 isolates was 1-16 μg/ml. 15 (12.5%) isolates carried qaca/b gene, 26 (21.7%) carried qacc gene, and 38 (31.7%) carried smr gene. conclusions maintenance of mrsa isolates in the attendance of low amounts of antiseptics could result in th...