HIGHLIGHTS Alginate/Chitosan is the second most abundant polysaccharide on earth. PRF (platelet-rich fibrin) potential to play adjunct roles in regenerative medicine. 3D printing grafts can increase wound healing capacity. Prospective of combining with different biomaterials promotes tissue regeneration.

Our increasing understanding of resident stem cell populations in various tissues of the adult body provides promise for the development of cell-based therapies to treat trauma and disease. With the sharp rise in the aging population, the need for effective regenerative medicine strategies for the aged is more important then ever. Yet, the vast majority of research fuelling our understanding of...

Hypoxiainducible factor-1 and its correlat ion wi th removing blood stasis for promoting tissue regeneration of t radi t ional Chinese principle of t reatment Yuan-Ying ZHU , Hua-Fa QUE (Department of Traditional Chinese Surgery , Longhua Hospital , Shanghai University of Traditional Chinese Medicine , Shanghai 200032 , China)

Fluorescent protein imaging, a promising tool in biological research, incorporates numerous applications that can be of specific use in the field of regenerative medicine. To enhance tissue regeneration efforts, scientists have been developing new ways to monitor tissue development and maturation in vitro and in vivo. To that end, new imaging tools and novel fluorescent proteins have been devel...

The regeneration of complex structures in adult salamanders depends on mechanisms that offer pointers for regenerative medicine. These include the plasticity of differentiated cells and the retention in regenerative cells of local cues such as positional identity. Limb regeneration proceeds by the local formation of a blastema, a growth zone of mesenchymal stem cells on the stump. The blastema ...

Laser radiation provides a means to control the fields of temperature and thermo mechanical stress, mass transfer, and modification of fine structure of the cartilage matrix. The aim of this outlook paper is to review physical and biological aspects of laser-induced regeneration of cartilage and to discuss the possibilities and prospects of its clinical applications. The problems and the pathwa...

Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after ...

Given the complexities of the mammalian CNS, its regeneration is viewed as the holy grail of regenerative medicine. Extraordinary efforts have been made to understand developmental neurogenesis, with the hopes of clinically applying this knowledge. CNS regeneration also involves glia, which comprises at least 50% of the cellular constituency of the brain and is involved in all forms of injury a...

Hyaline Cartilage Regeneration in a Large Osteochondral Defect Mori, H; Kondo, E; Kawaguchi, Y; Kitamura, N; Nagai, N; Munekata, M; Iida, H; +Yasuda, K +Department of Sports Medicine, Hokkaido University School of Medicine, Sapporo, Japan; Department of Orthopaedic Surgery, Kansai Medical University, Osaka, Japan; Department of Translational Research, Tohoku University School of Medicine, Senda...