Thrombotic thrombocytopenic purpura (TTP) is a medical emergency characterized by occlusive microangiopathy due to intravascular platelet aggregation. This event results in damage to the red blood cells (RBCs) known as microangiopathic hemolytic anemia (MAHA). Schistocytes are circulating fragments of damaged RBCs that have different morphological features including keratocytes, helmet cells, a...

Understanding why red blood cells (RBCs) move with an asymmetric shape (slipperlike shape) in small blood vessels is a long-standing puzzle in blood circulatory research. By considering a vesicle (a model system for RBCs), we discovered that the slipper shape results from a loss in stability of the symmetric shape. It is shown that the adoption of a slipper shape causes a significant decrease i...

The identification in the UK of 4 v-CJD infected patients thought to be due to the use of transfused Red Blood Cell units prepared from blood of donors incubating v-CJD raised major concerns in transfusion medicine. The demonstration of leucocyte associated infectivity using various animal models of TSE infection led to the implementation of systematic leuco-depletion (LD) of Red Blood cells co...

introduction: in a prospective study, we aimed to assess the value of enhanced rdw to predict sepsis and evaluate factors affecting length of icu stay and in-hospital mortality among sepsis patients. material and method: after exclusion of 27 patients, we included 160 adult patients with suspicious sepsis admitted at university affiliated hospital with 33 icu-beds from 2010 to 2012. nighty pati...

Red blood cells (RBCs) -- erythrocytes suspended in plasma tend to aggregate and form rouleaux. During aggregation the first stage consists formation of RBC doublets [Blood cells, molecules, diseases 25, 339 (1999)]. While aggregates are normally dissociated by moderate flow stresses, under some pathological conditions becomes irreversible, which leads high viscosity vessel occlusion. We perfor...

Blood rheology is completely determined by its major corpuscles which are erythrocytes, or red blood cells (RBCs). That is why understanding and correct mathematical description of RBCs behavior in blood is a critical step in modelling the blood dynamics. Various phenomena provided by RBCs such as aggregation, deformation, shear-induced diffusion and non-uniform radial distribution affect the p...

ObjectiveThis study aimed to determine whether or not transfusion of fresh red blood cells (RBCs) reduced the incidence new progressive multiple organ dysfunction syndrome compared with standard-issue RBCs in pediatric patients undergoing cardiac surgery.MethodsPreplanned secondary analysis Age Blood Children Pediatric Intensive Care Unit study, an international randomized controlled trial. Thi...

In microcirculation, red blood cells (RBCs) flowing through bifurcations may deform considerably due to combination of different phenomena that happen at the micro-scale level, such as: attraction effect, high shear, and extensional stress, all of which may influence the rheological properties and flow behavior of blood. Thus, it is important to investigate in detail the behavior of blood flow ...

Red blood cells (RBCs) undergo repeated deformation as they traverse blood vessel, capillaries and splenic cords; RBC deformability is therefore crucial in maintaining normal blood circulation. During falciparum malaria, parasite proteins interact with the spectrin network of host RBCs, moderately stiffening the ring stage infected cells (rings). The subtle modification in the deformability of ...