نتایج جستجو برای: rasburicase
تعداد نتایج: 472 فیلتر نتایج به سال:
HE PURPOSE OF THIS STUDY was to compare the plasma uric acid levels obtained by five accepted methods, and also to select a method most favorable for routine analysis. As the basis for such a selection, the following criteria have been considered: favorable comparison with the uricase method, ease of performance, and stability of the reagents. The selected method has been used to establish a no...
Gout is a clinical disorder caused by deposition of urate crystals in a joint leading to acute inflammatory response with acute pain. In severe and longstanding gout, the crystals accumulate in soft tissues such as cartilage, subcutaneous tissue or even veins leading to the development of tophi responsible for very large deposit formations and disability. Most cases of gout present with the sud...
After modification with monomethoxyl-poly(ethylene glycol)-5000, a recombinant intracellular uricase from Bacillus fastidiosus ATCC 29604 showed residual activity of about 65%, a thermo-inactivation half-life >85 h, a circulating half-life about 20 h in rats in vivo, consistent effects of common cations, and consistent optima for reaction temperature and pH. Thus, this uricase can be formulated...
CASE DESCRIPTION During second shift, a green-top specimen was received on ice with a request for uric acid determination. The young processing technician, unfamiliar with this situation, asked a supervisor why the specimen came down on ice. After the ordering provider was contacted, it was determined that a 9-year-old female with lymphoblastic lymphoma was being treated with rasburicase to mit...
We describe the interlaboratory testing of a candidate Reference Method (Part I) for uric acid in serum. The method is based on the ultrasound spectrophotometric quantitation of uric acid before and after incubation with uricase. A comprehensive investigation involving 12 laboratories was organized to document the transferability, intra- and interlaboratory precision, and general reliability of...
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