The idea of in vivo measurement of biological and/or biochemical processes was already envisaged in the 1930’s when the first artificially produced radionuclides of the biologically important elements carbon, nitrogen and oxygen were discovered with help of the then recently developed cyclotron. These radionuclides decay by pure positron emission and the annihilation of positron and electron re...

Pretargeted radioimmunotherapy (PRIT) using an anti-CD45 antibody (Ab)-streptavidin (SA) conjugate and DOTA-biotin labeled with β-emitting radionuclides has been explored as a strategy to decrease relapse and toxicity. α-emitting radionuclides exhibit high cytotoxicity coupled with a short path length, potentially increasing the therapeutic index and making them an attractive alternative to β-e...

Pretargeted radioimmunotherapy (PRIT) using an anti-CD45 antibody (Ab)–streptavidin (SA) conjugate and DOTA-biotin labeled with -emitting radionuclides has been explored as a strategy to decrease relapse and toxicity. -emitting radionuclides exhibit high cytotoxicity coupled with a short path length, potentially increasing the therapeutic index and making them an attractive alternative to -emit...

PURPOSE Conventional charged-particle imaging techniques - such as autoradiography - provide only two-dimensional (2D) black ex vivo images of thin tissue slices. In order to get volumetric information, images of multiple thin slices are stacked. This process is time consuming and prone to distortions, as registration of 2D images is required. We propose a direct three-dimensional (3D) autoradi...

BACKGROUND Optical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI. METHODOLOGY/PRINCIPAL FINDINGS By taking the advan...

Antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. Most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. Radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. True biodistribu...

Neuroendocrine tumours (NET) have a particular tendency to express functional receptors and/or uptake mechanisms. Radionuclides, such as (111)In-pentetreotide, a somatostatin analogue, which bind to somatostatin receptors, present an imaging modality that has been used for both the diagnosis and staging of NET. Scintigraphy with (111)In-pentetreotide can identify lesions beyond the diagnostic s...

The accumulation of radionuclides by plants acting as a monitoring system in the environment may occur by two modes; foliar absorption by the leaves and shoot of the plant, or by root uptake from the soil. Data on plant accumulation of radionuclides may be obtained from studies of fission product radionuclides deposited as worldwide fallout, and from tracer studies of plant physiology. The epid...

Background: A field study on the transfer of primordial radionuclides 238U, 232Th, 40K and fallout radionuclides 210Po in different plant species in tropical forest of western Ghats environment is presented. Material and Methods: The Top storey, Second storey, Shrubs and epiphytic plant species were chosen and concentration of these radionuclides in plant and soil were measured by employing gam...

antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. true biodistribution o...