The direct electrophilic no-carrier-added (n.c.a.) aromatic radioiodination was examined using various metal salts in trifluoroacetic acid (TFA) as in situ oxidation agents. Two different types of metal salts were used comprising TFAsoluble (Pb(CH3CO2)4, Mn(CH3CO2)3, KMnO4, Tl(CF3CO2)3, AgCF3SO3) and TFA-insoluble (Ce(CF3SO3)4, RuCl3, FeBr3, K2Cr2O7) salts. Optimization of both labelling system...

Microfluidic technology has been used to perform [(11)C]carbonylation reactions using solutions containing [(11)C]CO in the form of the complex, copper(i)tris(3,5-dimethylpyrazolyl)borate-[(11)C]carbonyl (Cu(Tp*)[(11)C]CO). The synthesis of the model compound [(11)C]N-benzylbenzamide and the known tracer molecule [(11)C]trans-N-[5-(2-flurophenyl)-2-pyrimidinyl]-3-oxospiro[5-azaisobenzofurane-1(...

Introduction: The mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14C] clozapine with suita...

A procedure based on radiochemical neutron activation analysis was developed for the determination of chromium in biological materials. The procedure consists of irradiation of reference and test samples in a nuclear reactor, microwave sample digestion, selective and quantitative radiochemical separations of chromium and gamma-ray spectrometric measurement of 51Cr. Separation of chromium from t...

A synthesis of [“Qcopolamine capable of clinical delivery of this agent in high specific activity is described. The precursor [“Clformaldehyde was produced by catalytic oxidation of [“C]CH,OH over metallic silver and was used to N-“C-methylate norscopolamine using aqueous neutral potassium phosphite as the reducing agent. The labeling reaction was complete after 5min at 7580°C and the [“Clscopo...

Halogens (fluorine, chlorine, bromine and iodine) were determined by activation analyses (neutron activation analysis (NAA), photon activation analysis (PAA) and prompt gamma-ray analysis (PGA)) for geological and cosmochemical solid samples. We studied how each analytical method was for the determination of trace amounts of halogens in rock samples. Radiochemical NAA (RNAA) showed the highest ...

The final data of the Gallex and GNO radiochemical experiments have been searched for possible time modulations of the solar neutrino capture rate using the LombScargle periodogram and the maximum likelihood methods. Both analyses, performed using the raw data, do not support the presence of a time variability with characteristic periods resembling those of rotation of the solar magnetic fields...

The instant thin-layer chromatographic method of determining the radiochemical purity of (99m)Tc-tetrofosmin recommended by the manufacturer uses a mixture of acetone and dichloromethane (35:65 v/v) as the solvent and a silica gel (SG) strip as the solid phase. Currently, SG strips are not available commercially and an alternative solid phase is needed. The present study reports that silicic ac...