Background: Measurement of absolute or differential renal function using radiotracers plays an important role in the clinical management of various renal diseases. Gamma camera quantitative methods in approximation of renal clearance may potentially be as accurate as plasma clearance methods. However some critical factors such as kidney depth and background counts are still troublesome in...

We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays for the first time. Here, we present the results of our on-site pilot gamma-imaging-spectroscopy with ETCC at three contaminated locations ...

Although radioactive iodine imaging and therapy are one of the earliest applications of theranostics, there still remain a number of unresolved clinical questions as to the optimization of diagnostic techniques and dosimetry protocols. I-124 as a positron emission tomography (PET) radiotracer has the potential to improve the current clinical practice in the diagnosis and treatment of differenti...

Typical features of lightning distribution in the mountain area Mt. Cimone (2165 m a.s.l., Northern-Central Italy) have been studied through detections provided by ground-based LIghtning NETwork data (LINET) and Lightning Imaging Sensor (LIS) onboard International Space Station (ISS-LIS). This study was performed within context Gamma-Flash program, which includes situ observation high-energy ra...

Several groups have reported the development of dual modality Gamma camera/optical imagers, which are useful tools for investigating biological processes in experimental animals. While previously reported dual modality imaging instrumentation usually employed a separated gamma camera and optical imager, we designed a detector using a position sensitive photomultiplier tube (PSPMT) that is capab...

With flavone as a structural template, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies and ab initio calculations were performed on a series of flavonoids. A reasonable pharmacophore model was built through CoMFA, CoMSIA, and HQSAR analyses and electrostatic potential calculations. A plausible binding mode for flavonoids with GABA(A) receptors was rationalized. ...

Objective(s): In recent years, the application of radiopharmaceuticals in nuclear medicine has increased substantially. Following the diagnostic procedures performed in nuclear medicine departments, such as myocardial perfusion imaging, patients generally receive considerable doses of radiation. Normally, radiation-induced DNA damages are expected following exposure to a low-dose ionizing radia...