نتایج جستجو برای: purkinje

تعداد نتایج: 7006  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
H Hirai T Launey

It is known that cerebellar granule cells are powerful inducers for the differentiation of Purkinje cells. However, the detailed mechanism of this regulation has not yet been clarified. Here, using cerebellar neuronal culture, we show that the activation of NMDA receptors expressed by granule cells triggers the signaling pathway for the dendritic differentiation of Purkinje cells. This signal h...

Journal: :Circulation research 1987
D A Rawling R W Joyner

The normal cardiac activation sequence requires propagation of the action potential from the subendocardial Purkinje network into the underlying ventricular muscle cells. This process occurs at specific junctional sites distributed over the endocardial surface of both ventricles. At these junctional sites, action potentials can be recorded from cells that appear to be interposed between the Pur...

Journal: :Journal of neurophysiology 2015
Haibo Zhou Kai Voges Zhanmin Lin Chiheng Ju Martijn Schonewille

The massive computational capacity of the cerebellar cortex is conveyed by Purkinje cells onto cerebellar and vestibular nuclei neurons through their GABAergic, inhibitory output. This implies that pauses in Purkinje cell simple spike activity are potentially instrumental in cerebellar information processing, but their occurrence and extent are still heavily debated. The cerebellar cortex, alth...

2014
Atsushi Yokoyama Kousaku Ohno Asao Hirano Masayuki Shintaku Masako Kato Kazuhiko Hayashi Shinsuke Kato

BACKGROUND To clarify the pathogenesis of cerebellar Purkinje cell death in patients with Menkes kinky hair disease (MD), a disorder of copper absorption, we investigated the morphological and functional abnormalities of residual Purkinje cells in MD patients and the mechanism of cell death. METHODS Seven MD patients and 39 neurologically normal autopsy cases were studied. We performed histop...

Journal: :Endocrinology 2003
Hirotaka Sakamoto Yukio Mezaki Hanako Shikimi Kazuyoshi Ukena Kazuyoshi Tsutsui

Neurosteroids are synthesized de novo in the brain, and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the Purkinje cell possesses intranuclear receptor for progesterone and actively produces progesterone de novo from cholesterol only during rat neonatal life, when cerebellar cortical formation occurs dramatically. We have further demonstrated...

2012
Junbeom Park Young-Hoon Kim Chun Hwang Hui-Nam Pak

PURPOSE We hypothesized that Purkinje potential and their preferential conduction to the left ventricle (LV) posteroseptum during sinus rhythm (SR) are part of reentrant circuits of idiopathic left ventricular tachycardia (ILVT) and reentry anchors to papillary muscle. MATERIALS AND METHODS In 14 patients with ILVT (11 men, mean age 31.5±11.1 years), we compared Purkinje potential and prefere...

2014
Marie K. Bosch Jeanne M. Nerbonne David M. Ornitz

Viral-vector mediated gene transfer to cerebellar Purkinje neurons in vivo is a promising avenue for gene therapy of cerebellar ataxias and for genetic manipulation in functional studies of animal models of cerebellar disease. Here, we report the results of experiments designed to identify efficient methods for viral transduction of adult murine Purkinje neurons in vivo. For these analyses, sev...

Journal: :Circulation research 1984
R D Veenstra R W Joyner D A Rawling

We have studied in vitro preparations of canine right and left papillary muscles to determine the excitation sequences of the Purkinje and ventricular cells, using both monopolar surface electrodes and intracellular microelectrodes. Our results show, for right papillary muscles, that the Purkinje layer covers the basal part of the muscle, and that activation from the right bundle branch propaga...

2011
Megumi Kaneko Kazuhiko Yamaguchi Mototsugu Eiraku Motohiko Sato Norio Takata Yoshimoto Kiyohara Masayoshi Mishina Hajime Hirase Tsutomu Hashikawa Mineko Kengaku

Dendrite arborization patterns are critical determinants of neuronal connectivity and integration. Planar and highly branched dendrites of the cerebellar Purkinje cell receive specific topographical projections from two major afferent pathways; a single climbing fiber axon from the inferior olive that extend along Purkinje dendrites, and parallel fiber axons of granule cells that contact vertic...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Lorenzo Magrassi Piercesare Grimaldi Adalberto Ibatici Mirko Corselli Laura Ciardelli Sandra Castello Marina Podestà Francesco Frassoni Ferdinando Rossi

Fusion of bone marrow-derived cells with adult Purkinje cells in the cerebellum gives rise to binucleated Purkinje cells. Whether fusion can be modulated by epigenetic factors and whether fused neurons are stable has remained unclear. Here, we show that in mice and rats, partial ablation of Purkinje cells and local microglial activation in the absence of structural damage to the cerebellum incr...

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