In light of recent data showing that both helper and cytotoxic T cells can detect even a single molecule of an agonist peptide-MHC, alphabeta T cells are clearly a type of sensory cell, comparable to any in the nervous system. In addition, endogenous (self) peptides bound to MHCs are not just important for thymic selection, but also play an integral role in T cell activation in the response to ...

OBJECTIVE To investigate the relationship between mode of delivery, perineal trauma and dyspareunia. DESIGN Prospective cohort study. SETTING Six maternity hospitals in Melbourne, Australia. SAMPLE A total of 1507 nulliparous women recruited in the first and second trimesters of pregnancy. METHOD Data from baseline and postnatal questionnaires (3, 6, 12 and 18 months) were analysed usin...

Prospective data on depressive symptoms and blood pressure are scarce, and the impact of age on this association is poorly understood. The present study examines longitudinal trajectories of depressive episodes and the probability of hypertension associated with these trajectories over time. Participants were 6889 men and 3413 women, London-based civil servants aged 35 to 55 years at baseline, ...

background although current data shows a positive association between obesity and development of coronary heart disease (chd) in general population, there is limited data on the important protective role of central or general obesity in patients with prevalent chd or the “obesity paradox”, from this region. conclusions results of this study demonstrated an apparently protective effect for overw...

The Mexico City Prospective Study (Estudio Mexicano de Cohorte Para Enfermedades Crónicas en una Población Metropolitana) is a blood-based cohort study involving follow-up of 150 000 adults (50 000 men and 100 000 women) who were aged at least 35 years when recruited in 1998–2004. The study resulted from discussions in the early 1990s about how best to measure the changing health effects of tob...

Methodological challenges arise when one uses various Veterans Health Administration (VHA) data sources, each created for distinct purposes, to characterize length of stay (LOS). To illustrate this issue, we examined how algorithm choice affects conclusions about mental health condition (MHC)-related differences in LOS for VHA patients with diabetes nationally (n = 784,321). We assembled a reco...

background in the golestan cohort study that was launched to investigate the causes of esophageal cancer, a complete biospecimen bank was established for storage of collected blood, urine, hair, and nail samples. the objective of this study was to evaluate the feasibility of nail samples as a biomarker of selected trace elements status. methods thirty toenail samples were selected randomly from...

background: workplace stress is known to be related with many behavioral and disease outcomes. however, little is known about its prospective relationship with measures of cognitive decline. objective: to investigate the association of job strain, psychological demands and job control on cognitive decline. methods: participants from framingham offspring cohort (n=1429), were assessed on job str...