alzheimer's disease is considered the most common cause of dementia. at present, no definite cure is available for healing the disorders and stopping the disease progress. the aim of this study is to study the effects of piracetam, rivastigmine and their joint consumption on mmse score status in patients with alzheimer disease. this interventional study was carried out on 64 patients with alzhe...

We have demonstrated that, in the rat hippocampal formation, withdrawal from chronic alcohol consumption aggravates the ethanol-induced loss of pyramidal neurons and dentate granule cells. We have also shown that intracerebral grafting and piracetam could have a protective effect in these conditions. In this study we utilized immunocytochemical methods to investigate whether gamma-aminobutyric ...

A dose dependent enhancement of memory was observed with A. racemosus and C. pluricaulis treatment as compared to control group when tested on second day. A. racemosus and C. pluricaulis at the dose of 200 mg/kg, po showed significantly higher percent retentions, than piracetam. Multiple treatment with A. racemosus and C. pluricaulis for three days also demonstrated significant dose dependent i...

Context Breath-holding spells (BHS) are a non-epileptic event where the child involuntarily stops breathing, typically for less than one minute, varying from several times daily to few month. 1 There two types of BHS: cyanotic and pallid; occurs in response fear or anger, causing oxygen desaturation loss consciousness, pallid can be triggered by pain fear, pallor, desaturation, seizure-like mov...

Objective of this study was to evaluate Guggul extract for the treatment of Alzheimer’s disease using scopolamine induced amnesia in mice on Morris water maze. Guggul extract (50mg/kg) was administered orally for fifteen successive days followed by Scopolamine (0.4 mg/kg i.p.) from 15 th to 18 th day in mice. Morris water maze was employed to evaluate learning and memory using parameter like Es...

The present study evaluated in mice the possible modification of psychostimulant methamphetamine (MET) effects by co-administration of piracetam (PIR) and the development of behavioural sensitisation to the psychostimulant in the case of combined treatment. On the Day 1 mice were randomly allocated into 4 groups and control open field test was performed. On the Day 7, after 5 days without treat...

Results: Th e administration of haloperidol (2 mg/kg, IP) resulted in signifi cant catalepsy. Piracetam (in dosages of 50, 100, and 300 mg/kg) given IP at the time of haloperidol administration reduced the duration of catalepsy by 24.4%, 32.3%, and 48.2%, respectively. Piracetam given as a 30-min pretreatment reduced the duration of catalepsy by 59.5%, 72.3%, and 78.2%, respectively. Vinpocetin...

The role of the voltage-gated K+ channels in the effect of some nootropics was investigated. Earlier, the multiple effect of high concentrations of two nootropics, piracetam and its peptide analogue GVS-111 [Seredenin et al. (1995), US Patent No. 5,439,930], on Ca2+ and K+ currents of molluscan neurons was shown [Solntseva et al. (1997), General Pharmacology 29, 85-89]. In the present work, we ...

Following 15 days' treatment with saline, 48 mg/kg rubidium chloride, 5 mg/kg imipramine hydrochloride, 10 mg/kg sodium phenobarbitone, 1000 mg/kg piracetam, or 0.20 mg/kg strychnine nitrate all administered intraperitoneally, mice were evaluated by habituation of exploratory activity using an open-field apparatus. In control animals a significant (P less than 0.05) decrease in open-field respo...

Diffraction and spectroscopic methods were evaluated for quantitative analysis of binary powder mixtures of FII(6.403) and FIII(6.525) piracetam. The two polymorphs of piracetam could be distinguished using powder X-ray diffraction (PXRD), Raman and near-infrared (NIR) spectroscopy. The results demonstrated that Raman and NIR spectroscopy are most suitable for quantitative analysis of this poly...