Lysosomal storage diseases (LSDs) are a group of genetic disorders due to defects in any aspect of lysosomal biology. During the past two decades, different approaches have been introduced for the treatment of these conditions. Among them, enzyme replacement therapy (ERT) represented a major advance and is used successfully in the treatment of some of these disorders. However, ERT has limitatio...

BACKGROUND A key procedure of the rhythm control strategy in atrial fibrillation (AF) is cardioversion to normal sinus rhythm. The aim of the present study was to provide a review of treatment patterns for the cardioversion of patients with AF in a hospital setting in Poland and document the success rate of various cardioversion procedures. METHODS We herein present the results from Poland of...

pharmacological responses is the formation of a complex between the ligand (or drug or molecule) and its site of action (Taylor & Insel, 1990). Competitive binding experiments ascertain how specific the interaction is between a ligand and its binding site by examining the ability of various compounds to compete with a radiolabelled reference probe for the site. The more potently a drug binds to...

Citation: Rizzo R, Pellico A, Silvestri PR, Chiarotti F and Cardona F (2018) A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. Front. Psychiatry 9:100. doi: 10.3389/fpsyt.2018.00100 a randomized controlled Trial comparing Behavioral, educational, and Pharmacological Treatments in Youths With ...

AIMS To estimate the prevalence of self-reported pharmacological neuroenhancement (PNE) with prescription or recreational drugs among the Swiss general population and correlates of PNE. DESIGN A population-based cross-sectional study using a self-administered online survey. SETTING A telephone-recruited highly representative internet panel in Switzerland. PARTICIPANTS A total of 10,171 Sw...