In this study, simple, fast and reliable cyclic voltammetry (CV), linear sweep voltammetry (LSV), square wave voltammetry (SWV) and differential pulse voltammetry (DPV) methods were developed and validated for determination of bosentan in pharmaceutical preparations. The proposed methods were based on electrochemical oxidation of bosentan at platinum electrode in acetonitrile solution containin...

Case-Based Design (CBD) applies a knowledge-based process to the knowledge commonly associated with Case-Based Reasoning (CBR) systems { the library of exemplars. This paper investigates the problems in using commercial CBR tools, primarily aimed at classi cation applications, for a more knowledge intensive CBD task, and proposes techniques that overcome some of these di culties. This work resu...

To evaluate the influence of different variables on tablet formulations containing enalapril maleate and indapamide as active substances, two separate experimental designs were employed: one for evaluating powder properties and the other for tablet characteristics. Because of the low active pharmaceutical ingredient content, it was hypothesized that both powder and tablet properties could be de...

Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the amount of rivaroxaban released in tablet dissolution studies. The dissolution profile of rivaroxaban was successfully determined with the validate...

Fast-disintegrating tablet (FDT) technology is one of the recent innovative technologies in pharmaceutical formulations, and the FDT formulation has become a fast-growing segment in oral drug delivery systems. FDTs can be administered easily without water, although taking water makes oral administration even easier. They are suitable for children, the elderly and anyone who has a difficulty in ...