نتایج جستجو برای: ph sensitive nanoparticles

تعداد نتایج: 539402  

2013
Neha Gulati Upendra Nagaich Shubhini A. Saraf

OBJECTIVE The objective of the research was to formulate and evaluate sumatriptan succinate-loaded chitosan nanoparticles for migraine therapy in order to improve its therapeutic effect and reduce dosing frequency. MATERIAL AND METHODS The Taguchi method design of experiments (L9 orthogonal array) was applied to obtain the optimized formulation. The sumatriptan succinate-loaded chitosan nanop...

Journal: :Nanoscale 2015
Chieh-Jui Tsou Chih-Hao Hsia Jia-Yin Chu Yann Hung Yi-Ping Chen Fan-Ching Chien Keng C Chou Peilin Chen Chung-Yuan Mou

Continuous and simultaneous 3D single-particle movement and local pH detection in HeLa cells were demonstrated for the first time by combining fluorescent mesoporous silica nanoparticles (FMSNs) and a single-particle tracking (SPT) technique with a precision of ∼10 nm. FMSNs, synthesized by the co-condensation of both pH-sensitive and reference dyes with a silica/surfactant source, allow long-t...

2016
Dikran Kesal Stephanie Christau Patrick Krause Tim Möller Regine von Klitzing

The impact of electrostatic attraction on the uptake of gold nanoparticles (AuNPs) into positively charged strong poly-[2-(Methacryloyloxy) ethyl] trimethylammonium chloride (PMETAC) polyelectrolyte brushes was investigated. In this work, PMETAC brushes were synthesized via surface-initiated atom transfer radical polymerization (Si-ATRP). PMETAC/AuNP composite materials were prepared by incubat...

Journal: :Bioconjugate chemistry 2005
Michael J Heffernan Niren Murthy

In this report, we present an acid-sensitive drug delivery vehicle, termed polyketal nanoparticles, which are designed to target therapeutics to the acidic environments of tumors, inflammatory tissues, and phagosomes. The polyketal nanoparticles are formulated from poly(1,4-phenyleneacetone dimethylene ketal) (PPADK), a new hydrophobic polymer which contains ketal linkages in its backbone. The ...

Journal: :Chemical communications 2015
Yue Cao Ruo-Can Qian Da-Wei Li Yi-Tao Long

Herein, a pH-sensitive probe has been designed based on DNA modified gold nanoparticles (AuNPs) for Raman/fluorescence dual-imaging of the intracellular pH distribution. In the acidic environment of cancer cells, the configuration change of DNA on the probe surface could turn "on" Raman/fluorescence signals simultaneously.

Journal: :Nanoscale 2014
Ping Gong Yueting Yang Huqiang Yi Shengtao Fang Pengfei Zhang Zonghai Sheng Guanhui Gao Duyang Gao Lintao Cai

pH is an important control parameter for maintenance of cell viability and tissue functions. pH monitoring provides valuable information on cell metabolic processes and the living environment. In this study, we prepared dual pH-sensitive, fluorescent dye-loaded polypeptide nanoparticles (DPNs) for ratiometric sensing of pH changes in living cells. DPNs contain two types of dyes: N-(rhodamine B)...

Journal: :Chemical communications 2010
Juying Lei Lingzhi Wang Jinlong Zhang

Incorporation of a dual-FRET dye pair into mesoporous silica nanoparticles yields sensitive and sensing-range tunable nanosensors with good reversibility that can be used for ratiometric pH measurements under a single-wavelength excitation.

Journal: :journal of applied pharmaceutical science 2021

Fabrication, Physicochemical Characterization and Evaluation of In vitro Anticancer Efficacy a Novel pH Sensitive Polymeric Nanoparticles for Efficient Delivery Hydrophobic Drug against Colon CancerManikandan Mahalingam, Kannan Krishnamoorthy

Journal: :Chemical communications 2009
Eryun Yan Yin Ding Changjing Chen Rutian Li Yong Hu Xiqun Jiang

Hybrid hollow nanospheres of chitosan-silica templated by chitosan-poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.

2014
Núria Mas Irene Galiana Silvia Hurtado Laura Mondragón Andrea Bernardos Félix Sancenón María D Marcos Pedro Amorós Nuria Abril-Utrillas Ramón Martínez-Máñez José Ramón Murguía

pH-sensitive gated mesoporous silica nanoparticles have been synthesized. Increased extracellular pH and internalization into living yeast cells triggered molecular gate aperture and cargo release. Proper performance of the system was demonstrated with nanodevices loaded with fluorescein or with the antifungal agent tebuconazole. Interestingly, nanodevices loaded with tebuconazole significantly...

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