Authors’ Affi liation: Oncology Research Unit, Pfi zer Worldwide Research and Development, San Diego, California Corresponding Author: Robert T. Abraham, Oncology Research Unit, Pfi zer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121. Phone: 858-526-4772; E-mail: Robert.Abraham@ pfi zer.com doi: 10.1158/2159-8290.CD-14-0332 ©2014 American Association for ...

The effect of peritoneal fluid (PF) on the human sperm acrosome reaction (AR) was tested. Sperm was pre-incubated with PF and the AR was induced by calcium ionophore A23187 and a neoglycoprotein bearing N-acetylglycosamine residues (NGP). The AR induced by calcium ionophore was inhibited 40% by PF from controls (PFc) and 50% by PF from the endometriosis (PFe) group, but not by PF from infertile...

OBJECTIVE There has been a consistent concern about the inadvertent disclosure of personal information through peer-to-peer file sharing applications, such as Limewire and Morpheus. Examples of personal health and financial information being exposed have been published. We wanted to estimate the extent to which personal health information (PHI) is being disclosed in this way, and compare that t...

Vegetation fires are the second largest source of greenhouse gas emissions to the atmosphere. The reduction of the climatic impact of these emissions is related to the vegetation susceptibility to fire (fire risk), as well as to the understanding of possible implications of changes in atmospheric circulation on fire risk in the nearfuture. This study evaluates the environmental susceptibility t...

A comparison in the context of sparse matrices is made between the Product Form of the Inverse PFI (a form of Gauss-Jordan elimination) and the Elimination Form of the Inverse EFI (a form of Gaussian elimination). The precise relation of the elements of these two forms of the inverse is given in terms of the nontrivial elements of the three matrices L, U, U~l associated with the triangular fact...

Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene transcription programs during development and stem cell differentiation. BAF complexes contain an ATP (adenosine 5'-triphosphate)-driven remodeling enzyme (either BRG1 or BRM) and multiple protein interaction domains including bromodomains, an evolutio...

INTRODUCTION The current standard of care for ovarian cancer is optimal cytoreduction with adjuvant chemotherapy based on a platinum/taxane combination. Although the response rate to this therapy is high, most patients ultimately relapse. Response to second-line therapy and prognosis are linked to the platinum-free interval (PFI); when both improve, the PFI increases. As a result, there is an i...

Abstract The interpretation of feature importance in machine learning models is challenging when features are dependent. Permutation (PFI) ignores such dependencies, which can cause misleading interpretations due to extrapolation. A possible remedy more advanced conditional PFI approaches that enable the assessment on all other features. Due this shift perspective and order correct interpretati...

Pyruvate formate-lyase (also called formate acetyltransferase; EC 2.3.1.54; PFI .) catalyses the thiolytic cleavage of pyruvate by CoA, yielding acetyl-CoA and formate. This reaction is the key step in the glucose-fermentation route in Escherichziz coli and various other bacteria. Operationally, it resembles the (B-keto)thiolase reaction of the fatty-acid degradation cycle. The mechanism of pyr...