نتایج جستجو برای: permeation enhancer

تعداد نتایج: 29062  

2014
Betül Aktar Meryem Sedef Erdal Olcay Sagirli Sevgi Güngör

The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinole...

Journal: :International journal of pharmaceutics 2011
Hussain Fatakdawala Scott A Uhland

Simple, safe and effective permeability enhancers are crucial for successful non-invasive drug delivery methods. We seek local permeability augmentation mechanisms for integration into passive or active architectures in order to enable novel therapeutic delivery routes of the target drug while minimizing drug formulation challenges. This study explores the efficacy of hydrogen peroxide (HP) as ...

2016
Xingxing Dai Qianqian Yin Guang Wan Ran Wang Xinyuan Shi Yanjiang Qiao

Borneol is a natural permeation enhancer that is effective in drugs used in traditional clinical practices as well as in modern scientific research. However, its molecular mechanism is not fully understood. In this study, a mixed coarse-grained model of stratum corneum (SC) lipid bilayer comprised of Ceramide-N-sphingosine (CER NS) 24:0, cholesterol (CHOL) and free fatty acids (FFA) 24:0 (2:2:1...

Cheong-Weon Cho Sang-Chul Shin,

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

Journal: :Alternatives to laboratory animals : ATLA 2008
Monika Schäfer-Korting Ashraf Mahmoud Simone Lombardi Borgia Barbara Brüggener Burkhard Kleuser Sylvia Schreiber Wolfgang Mehnert

A protocol for percutaneous absorption studies has been validated, based on the use of reconstructed human epidermis (RHE) and aqueous solutions of test substances. However, it is often the case that it is more-complex formulations of drugs or chemicals which will make contact with the skin surface. To investigate whether RHE and the reconstructed full-thickness skin model (FT-model) can be use...

Journal: :The Journal of pharmacy and pharmacology 2010
M J Traynor R B Turner C R G Evans R H Khengar S A Jones M B Brown

OBJECTIVES The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. METHODS Initially a modified Franz cell was used, where sections of human nail serve as the barrier through which drug penetrates into an agar-filled chamber infected with dermatophyt...

Cheong-Weon Cho Sang-Chul Shin,

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

Journal: :pharmaceutical and biomedical research 0
nida akhtar department of pharmaceutics, rajiv academy for pharmacy, p.o. chhatikara, mathura- 281001, uttar pradesh, india soniya sahu department of pharmaceutics, rajiv academy for pharmacy, p.o. chhatikara, mathura- 281001, uttar pradesh, india kamla pathak department of pharmaceutics, pharmacy college saifai, uttar pradesh university of medical sciences, saifai, etawah-206130, uttar pradesh, india.

onychomycosis constitutes the most common fungal infection of nail affecting finger and toe nails as well. antifungals found to be effective in the treatment of onychomycosis. however, transport of oral antifungal agents exhibits more toxicity and requires longer treatment period. medicated nail lacquers proved to cause lesser toxicity and required shorter treatment period. it provides not only...

2013
Nitin Sharma Giriraj T Kulkarni Anjana Sharma

Purpose: To develop a safe mucoadhesive gel for nasal drug delivery using okra polysaccharide. Methods: Rizatriptan benzoate nasal gel was developed using natural polysaccharide obtained from the Abelmoschus esculentus. The gel formulation was characterized for pH, viscosity, mucoadhesion, and in vitro permeation. Permeation parameters obtained include drug flux (j), permeation coefficient (kP)...

2010
M. A. Saleem Sumanji Bala Liyakat A. Aeajaz

The ability of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for β-cyclodextrin and hydroxypropyl-β-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. T...

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