Background: Fever and neutropenia (FN) is a common complication of pediatric cancer treatment, but hospital utilization patterns for this condition are not well described. Methods: Data were analyzed from the Kids’ Inpatient Database (KID), an all-payer US hospital database, for 2009. Pediatric FN patients were identified using: age ≤19 years, urgent or emergent admit type, non-transferred, and...

Cancer is a significant health problem in the adolescent and young adult population. Confusion exists within the field of pediatric oncology with respect to the definition of childhood cancer, since most population-based incidence studies define childhood cancer on the basis of age alone. We recommend that the scope of pediatric oncology include the study and treatment of cancer in infants, chi...

background: understanding the differences in genetics of malignancies is crucial for therapeutic decisions. this systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. material and methods: we performed a systematic review of the literature published on genetics of pediatrics bone tumors, using pubmed, google scholar, scie...

The American Society of Pediatric Hematology/Oncology (ASPHO) 2012 Annual Meeting included an interactive workshop on the rapidly expanding topic of hereditary cancer syndromes in children. As discussed, the Sword of Damocles is an appropriate analogy to consider when approaching families with extraordinarily high risk for developing cancer [1]. This expression is based on the story of a sword ...

Background: In this study, we examined the epidemiologic characteristics of childhood brain tumors in patients referred to MAHAK Pediatric Cancer Treatment and Research Center (one of the main national referral centers for childhood malignancies in Iran) for treatment. Materials and Methods: This cohort (simple sampling) study consisted of 198 children less than 15 year old with CNS tumor ref...

BACKGROUND Recently published analyses showed that computed tomography (CT) scans in pediatric patients are associated with increased risk of radiation-related cancer. These analyses were based on data collected both from either hospitals and primary care services. Study objectives were to characterize cohorts of pediatric patients in Israel undergoing CT scans in primary care compared to hospi...

Purpose Pediatric cancer survivors often experience late effects secondary to cancer therapy, but their choices for symptom management is largely unknown. Many of these late effects can be treated by lifestyle changes such as diet, exercise, and conventional supplements. Although the use of lifestyle therapies appears common in children and adolescents, including pediatric cancer survivors, the...

BACKGROUND Pediatric Phase I cancer trials are critical for establishing the safety and dosing of anti-cancer treatments in children. Their implementation, however, must contend with the rarity of many pediatric cancers and limits on allowable risk in minors. The aim of this study is to describe the risk and benefit for pediatric cancer Phase I trials. METHODS AND FINDINGS Our protocol was pr...

1Pediatric Hematology and Oncology, University of Frankfurt, Germany; 2Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany; 3Children’s Cancer Research Institute, St Anna Kinderspital and Children’s Cancer Research Institute (CCRI), Vienna, Austria; 42nd Medical School, Charles University, Prague, Czech Republic; 5Department of Pediatric Hematology and Oncology, Un...