نتایج جستجو برای: pde3b

تعداد نتایج: 110  

Journal: :American journal of physiology. Endocrinology and metabolism 2007
J Polak C Moro E Klimcakova M Kovacikova M Bajzova M Vitkova Z Kovacova R Sotornik M Berlan N Viguerie D Langin V Stich

Thyroid dysfunction is associated with several abnormalities in intermediary metabolism, including impairment of lipolytic response to catecholamines in subcutaneous abdominal adipose tissue (SCAAT). Atrial natriuretic peptide (ANP) is a powerful lipolytic peptide; however, the role of ANP-mediated lipolysis in thyroid disease has not been elucidated. The aim of this study was to investigate th...

2017
Na Xiao Le-Le Yang Yi-Lin Yang Li-Wei Liu Jia Li Baolin Liu Kang Liu Lian-Wen Qi Ping Li

Endoplasmic reticulum (ER) stress, inflammation, and lipolysis occur simultaneously in adipose dysfunction and contribute to insulin resistance. This study was designed to investigate whether ginsenoside Rg5 could ameliorate adipose dysfunction and prevent muscle insulin resistance. Short-term high-fat diet (HFD) feeding induced hypoxia with ER stress in adipose tissue, leading to succinate acc...

Journal: :American journal of physiology. Endocrinology and metabolism 2009
Christine Berggreen Amélie Gormand Bilal Omar Eva Degerman Olga Göransson

Protein kinase B (PKB) is known to mediate a number of biological responses to insulin and growth factors, its role in glucose uptake being one of the most extensively studied. In this work, we have employed a recently described allosteric inhibitor of PKB, Akti, to clarify the role of PKB in lipid metabolism in adipocytes-a subject that has received less attention. Pretreatment of primary rat ...

Journal: :Diabetes 2002
Stuart J Netherton Sandra L Jimmo Daniel Palmer Douglas G Tilley Heather A Dunkerley Daniel R Raymond James C Russell P Marlene Absher E Helene Sage Robert B Vernon Donald H Maurice

Cardiovascular diseases represent a significant cause of morbidity and mortality in diabetes. Of the many animal models used in the study of non-insulin-dependent (type 2) diabetes, the JCR:LA-cp rat is unique in that it develops insulin resistance in the presence of obesity and manifests both peripheral and coronary vasculopathies. In this animal model, arterial vascular smooth muscle cells (V...

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