نتایج جستجو برای: pde3a

تعداد نتایج: 120  

Journal: :Molecular pharmacology 2002
Heather A Dunkerley Douglas G Tilley Daniel Palmer Hanguan Liu Sandra L Jimmo Donald H Maurice

Vascular smooth muscle cells (VSMC) in situ function to control contraction and are said to express a contractile phenotype. However, during development or in response to vascular damage, VSMC proliferate and express a more synthetic phenotype. A survey of literature values for contractile and synthetic VSMC phosphodiesterase (PDE) 3 and PDE4 activities identified a marked difference in the PDE...

Journal: :American journal of physiology. Endocrinology and metabolism 2005
Hisham S Elbatarny Donald H Maurice

An elevated circulating level of the adipocyte-derived satiety hormone leptin is an independent risk factor for cardiovascular disease. Because thrombus formation is a major cause of acute coronary events and leptin was shown previously to facilitate ADP-induced platelet aggregation, we chose to define the signaling events involved in leptin-mediated platelet activation. Using pharmacological, ...

2017
Anna Subbotina Aina W. Ravna Roy A. Lysaa Ruben Abagyan Ryszard Bugno Georg Sager

OBJECTIVES To determine the ability of 11 sildenafil analogues to discriminate between cyclic nucleotide phosphodiesterases (cnPDEs) and to characterise their inhibitory potencies (Ki values) of PDE5A1-dependent guanosine cyclic monophosphate (cGMP) hydrolysis. METHODS Sildenafil analogues were identified by virtual ligand screening (VLS) and screened for their ability to inhibit adenosine cy...

2009
Petra Gromova Sebastian Ralea Anne Lefort Frédérick Libert Brian P Rubin Christophe Erneux Jean-Marie Vanderwinden

Gastrointestinal stromal tumours (GIST) are thought to derive from the interstitial cells of Cajal (ICC) or an ICC precursor. Oncogenic mutations of the receptor tyrosine kinase KIT are present in most GIST. KIT K642E was originally identified in sporadic GIST and later found in the germ line of a familial GIST cohort. A mouse model harbouring a germline Kit K641E mutant was created to model fa...

Journal: :Blood 2004
Derek S Sim Glenn Merrill-Skoloff Barbara C Furie Bruce Furie Robert Flaumenhaft

Platelet accumulation at sites of vascular injury is the primary event in arterial thrombosis. Initial platelet accrual into thrombi is mediated by interactions of platelet adhesion receptors with ligands on the injured endothelium or in the sub-endothelial matrix. The role of intracellular signals in initial platelet accumulation at sites of endothelial injury, however, is the subject of debat...

Journal: :Endocrinology 2008
Avital Dov Eva Abramovitch Nasim Warwar Rafael Nesher

cAMP activates multiple signal pathways, crucial for the pancreatic beta-cells function and survival and is a major potentiator of insulin release. A family of phosphodiesterases (PDEs) terminate the cAMP signals. We examined the expression of PDEs in rat beta-cells and their role in the regulation of insulin response. Using RT-PCR and Western blot analyses, we identified PDE3A, PDE3B, PDE4B, P...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید