background: prostate cancer is one of the most commonly diagnosed cancers in males. tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. objective: to investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. methods: in this study expression of p53 was examined in p...

the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

recognition of the molecular mechanisms of camp action against dna damage-induced apoptosis can be useful to improve the efficacy of dna damaging therapeutic agents. considering the critical role of bcl-2-associated death promoter (bad) and p53 proteins in dna damage -induced apoptosis, the aim of this study was to assess the effect of camp-elevating agents on these proteins in doxorubicin-trea...

Abstract Objectives The aim of this study is to investigate the effects radiofrequency radiation (RFR) on apoptosis, proliferation, stress response, and inflammation markers in colorectal cancer cells. Methods We tested intermittent exposure RFR at different frequencies two cell lines; HCT-116 DLD-1. Protein levels were subsequently analyzed by ELISA. Results led a decrease P53, p-P53, p-P38, p...

Abstract BACKGROUND Metastatic involvement of the CSF by non-CNS neoplasms surpasses that primary brain tumors, although conventional glioblastoma (GBM) can occasionally be identified in CSF. Here, we apply Biocept’s CNSide test to examine a patient sample with GBM, verified an antibody against mutant p53. The p53 pathway is deregulated 84% patients and point mutations lead expression protein. ...

The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...

We investigated the effects of melatonin, cetuximab and cisplatin treatments alone or in combination on PANC-1 cells from a human pancreatic carcinoma ductal cell origin through viability gene expressions. The were left for 48 h incubation after applying chemicals cells. metabolic substances at end measured by MTT assay. expressions p21, p27, p53, p57, MDM2 KRAS determined RT-PCR. use melatonin...

background and objective: p53 is a suppressive gene that plays a key role in dna repair and apoptosis. the purpose of this study was to investigate the effect of p53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (scc) response to neoadjuvant chemoradiotherapy. patients and methods: in this retrospective cohort study, 44 patients with loca...