In bone engineering, the adhesion, proliferation and differentiation of mesenchymal stromal cells rely on signaling from chemico-physical structure of the substrate, therefore prompting the design of mimetic "extracellular matrix"-like scaffolds. In this study, three-dimensional porous poly-L-lactic acid (PLLA)-based scaffolds have been mixed with different components, including single walled c...

The aim of this study was to evaluate the bone repair using autogenous periosteum-derived cells (PDC) and bovine anorganic apatite and collagen (HA-COL). PDC from Wistar rats (n=10) were seeded on HA-COL discs and subjected to osteoinduction during 6 days. Critical-size defects in rat calvarias were treated with blood clot (G1), autogenous bone (G2), HA-COL (G3) and HA-COL combined with PDC (G4...

Introduction: A bone graft is a substitute material that has been widely used in grafting. In general, can be resorbable and replace normal the healing process within few months, because principle nature of osteoconduction, osteoinduction, osteogenic. One synthetic materials commonly hydroxyapatite (HA), which identical to crystal structure from bone. Review: Hydroxyapatite graft, most now due ...

We have developed a new drug-delivery system using reconstituted bone xenograft to treat chronic osteomyelitis. This material, which has the capabilities of osteoinduction and osteoconduction, was supplemented with up to 2000 times the minimum inhibitory concentration of gentamicin against Staphylococcus aureus to prepare a gentamicin-reconstituted bone xenograft-composite (G-RBX-C). In a rabbi...

BACKGROUND Polymethyl methacrylate (PMMA) bone cement is widely used for osteoplasty. However, previous studies have demonstrated the adverse effects of PMMA due to its excessive stiffness and heat production. Recently, calcium phosphate cement (CPC) that overcomes those negative effects has been successfully applied in osteoplasty. The potential problem of CPC is markedly less initial stiffnes...

Introduction: The nasopalatine cyst is a non-odontogenic cyst, located within the duct of maxilla, its diagnosis in most cases by routine radiological finding and other presence symptomatology; coming to generate pain, paresthesia visible signs such as facial deformities. Case description: objective this article make literature review presentation case 38-year-old male patient, who comes consul...

The osteogenic capacity of biomimetic calcium deficient hydroxyapatite microspheres with and without collagen obtained by emulsification of a calcium phosphate cement paste has been evaluated in an in vivo model, and compared with an injectable calcium phosphate cement with the same composition. The materials were implanted into a 5 mm defect in the femur condyle of rabbits, and bone formation ...

Calcium phosphate-based (CaP) bioceramic materials are widely used in the field of bone regeneration, both orthopaedics and dentistry, due to their good biocompatibility, osseointegration osteoconduction. The formation CaP coatings on high-strength implant such as titanium alloys combines superior mechanical properties metals with osteoconductive materials. In this work, electrochemically assis...

Bone morphogenetic proteins (BMPs) are a family of bone matrix polypeptides which have been isolated from a variety of mammalian species, including man. BMPs initiate chondroblastic differentiation in pluripotent mesenchymal progenitor cells, followed by the synthesis of new bone by enchondral ossification. BMPs have demonstrated the ability to induce healing of osteoperiosteal defects in sever...