BACKGROUND AND OBJECTIVES Oral submucous fibrosis (OSF) is a chronic condition of the oral cavity which results in permanent disability. A number of studies have proven that the management of premalignant diseases should include antioxidants. Therefore, a study was carried out to evaluate the efficacy of spirulina as an antioxidant adjuvant to corticosteroid injections in the management of 40 o...

This cross-sectional study was conducted to evaluate the prevalence of oral sub-mucous fibrosis among male school going children in a low socio-economic class and to analyze the relationship between oral submucous fibrosis and the use of various form of tobacco and areca nut. It was conducted on 54 male school going children aged between 10-19 years studying in classes VI to X of a public schoo...

OBJECTIVES To evaluate the efficacy of oral lycopene therapy in patients with oral submucous fibrosis and to compare these effects with a placebo. STUDY DESIGN Fifty-eight patients with oral submucous fibrosis formed the population for the study and were randomly divided into 3 groups, evaluated weekly over a 2-month period. Patients of group A (n = 21) received 16 mg of lycopene, those of gr...

Oral submucous fibrosis (OSF) is caused by aberrant collagen deposition in the oral mucosa. A chronic, creeping, scarring disease of cavity often involving pharynx and upper oesophagus how it's been described for centuries. It most dangerous premalignant condition evolve into malignant tumours 1.5% to 15% cases. found primarily India, Pakistan, Sri Lanka, Bangladesh. Submucous fibrosis, ulcerat...

Background: Oral submucous fibrosis (OSMF), now worldwide acknowledged as the disease of “Southeast Asia and Indian subcontinent”, has utmost malignant transformation prevalence amongst oral precancerous disorders. Increased vascularity that is neoangiogenesis been observed in superficial connective tissue region pre-cancerous lesions showing dysplasia. This could be...

Oral Submucous Fibrosis (OSMF) is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions people worldwide with prevalence rate 0.4% in Indian rural population. It results difficulty mouth opening can be to patient. needs timely diagnosis thus appropriate treatment administered depending on degree involvement. A case occurring 55 year old ma...

Oral submucous fibrosis (OSMF) is a crippling disorder which is confined almost exclusively to the Indian subcontinent. Despite its association with a significantly increased risk of cancer, the etiology is still not clear. An epidemiological assessment showed 0.4% prevalence for OSMF in Kerala, South India, which is among the highest recorded. Recently the National Tumour Registry in Trivandru...

Oral submucous fibrosis (OSF) is a premalignant condition caused by betel chewing. It is very common in Southeast Asia but has started to spread to Europe and North America. OSF can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption. OSF is a diagnosis based on clinical symptoms and confirmation by histopathology. Hypovascularity leading to blan...