The global high prevalence of diabetes mellitus has resulted into the development several oral hypoglycemic agents. However, these drugs have limited efficacy and harmful side effects, which call for search alternatives from natural sources. inhibition dipeptidyl peptidase-4 (DPP-4) activity increases level glucagon-like peptide-1 glucose-dependent insulinotropic polypeptide, in turn reduces hy...

OBJECTIVE To determine whether case subjects who were later diagnosed with type 2 diabetes utilized primary care differently from control subjects who remained free from diabetes. RESEARCH DESIGN AND METHODS We conducted a matched cohort study using the U.K. General Practice Research Database. Case subjects were aged 30-89 years, diagnosed with diabetes, and later prescribed oral hypoglycemic...

Transferrin (Tf) receptor-mediated transcytosis of insulin-transferrin conjugate (In-Tf) has been demonstrated in cultured human enterocyte-like Caco-2 cells. In the present report, oral delivery of insulin as a Tf conjugate in streptozotocin (STZ)-induced diabetic rats was investigated. Human insulin was conjugated at a 1:1 molar ratio to iron-loaded human Tf by a disulfide linkage. The stabil...

BACKGROUND The second-generation antipsychotic drug olanzapine is an effective pharmacological treatment for psychosis. However, use of the drug is commonly associated with a range of metabolic side effects, including glucose intolerance and insulin resistance. These symptoms have been accurately modelled in rodents. METHODS We compared the effects of 3 distinct classes of antidiabetic drugs,...

OBJECTIVE Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral antidiabetes drugs. RESEARCH DESIGN AND METHODS This study is a nested case-control analysis using the U.K.-based General Practice Research Data...

Momordica charantia (MC) fruit was subjected to phytochemical and pharmacological interaction studies with oral hypoglycemis in NIDDM patients. Phytochemical, chromatographical analysis and extraction of methanolic MC fruit soft (semi-solid form) in CCl4 + C6H6 solvent system yielded 15 diverse chemical constituents--alkaloids, glycosides, aglycone, tannin, sterol, phenol and protein. The CCl4 ...

INTRODUCTION Adherence to oral hypoglycemic agents is essential to reducing the poor health outcomes of populations at high risk for developing diabetes and its chronic complications. The goal of this study was to identify characteristics of patients in Hawaii least likely to adhere to oral hypoglycemic agents. METHODS This retrospective administrative data analysis included prescription refi...

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard.

The incidence of type 2 diabetes increases with age (1), and elderly people with this disease may be particularly susceptible to hypoglycemia due to long-acting oral antidiabetic drugs (OADs). The American Geriatric Society clinical guidelines on type 2 diabetes treatment in elderly people report that short-acting hypoglycemic agents are preferable to longer-acting agents (chlorpropramide), whi...

Patients who use insulin or oral hypoglycemic medications are at the greatest risk for hypoglycemia. These patients experience mild, self-treated hypoglycemic episodes about twice per week. Severe hypoglycemia, which requires the assistance of another person to regain euglycemia, is experienced at least once per year by 27% of patients treated with intensive insulin regimens. Hypoglycemia is th...