Pannexin1 proteins form communication channels at the cell plasma membrane surface, which allow transfer of small molecules and ions between intracellular compartment extracellular environment. In this way, pannexin1 play an important role in various cellular processes diseases. Indeed, a plethora human pathologies is associated with activation channels. The present paper reviews summarizes str...

introduction numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. these channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. in contrast to the sarcoplasmic reticulum + here potassium channels have been clearly identified, ...

Shaker channel mutants, in which the first (R362), second (R365), and fourth (R371) basic residues in the S4 segment have been neutralized, are found to pass potassium currents with voltage-insensitive kinetics when expressed in Xenopus oocytes. Single channel recordings clarify that these channels continue to open and close from -160 to +80 mV with a constant opening probability (Po). Although...