1. Daniel R. Pigmentation abnormalities In: Scher RK, Daniel CR, editors, Nails Therapy, Diagnosis & Surgery, Philadelphia: WB Saunders; 1990, p.153. 2. Tuffaneli D, Abraham RK, Dubois EI. Pigmentation from antimalarial therapy. Its possible relationship to the ocular lesions. Arch Dermatol 1963:88;419-26. 3. Johnson RA. Cutaneous manifestations of HIV disease. In: Fitzpatrick’s Dermatology in ...

Nail involvement in pemphigus vulgaris is rare. We describe 5 patients with pemphigus vulgaris presenting nail involvement. In this disease, nail manifestations present, by order of frequency, as chronic paronychia, onychomadesis, onycholysis, Beau's lines and trachyonychia. All our 5 cases presented with paronychia, and 1 of them also had Beau's lines. Treatment with prednisone and/or cyclopho...

A 75-year-old woman had a 2-year history of severe onycholysis and chloronychia (olive green discolouration) of most of her fingernails (Figure). Fungal infection had been excluded by microscopy and culture of nail scrapings. Some nails had superficial ridges and pits, as well as translucent orange-brown discolouration of the nail beds (the “oil drop” sign). This, along with a well defined, red...

CONTEXT Conventional chemotherapy leads to multiple adverse mucocutaneous complications such as oral mucositis, alopecia, ocular toxicity, and onycholysis. Limited pharmacologic interventions are available for preventing these clinical problems. OBJECTIVES This study aimed to critically review the role of cryotherapy (regional hypothermia) for alleviating these adverse symptoms. METHODS A n...

BACKGROUND Psoriasis is a disease of worldwide distribution with a prevalence of 1 to 3%. Nail psoriasis is estimated in 50% of patients with psoriasis, and in the presence of joint involvement, it can reach 80%. OBJECTIVE To study the nail changes - and their clinical implications - presented by patients with psoriasis vulgaris under surveillance in a university hospital from the south of Br...

Yeasts cause only 5-10% of onychomycosis; the most common yeast is Candida albicans, and rarely Trichosporon spp. is found. Recently, it has become an important cause of fungemia with a high mortality rate in immunocompromised patients. Superficial infections caused by Trichosporon spp., including piedra and onychomycosis, occur in immunocompetent patients. Herein, we report a case of a fungal ...

We report a 6-year-old girl who received a left-lobe live-related liver transplant for decompensated liver disease after a failed Kasai's surgery for biliary atresia. Preoperatively, her nails were white, dystrophic, brittle with severe onycholysis, clubbing and watch-glass deformities. Nail scrapings were negative for fungus. Five months after transplantation, her nails had become near normal....

Suggested scheme for the treatment of onychomycosis A stepped therapeutic approach to the treatment of onychomycosis is suggested. The risks of failure of treatment include the fungal involvement of the lunula portion, the lateral edge of the nail and the subungual area. Infection of the subungual area may lead to extensive onycholysis or dermatophytoma presenting as a hard subungual mass or as...