Background: This study was conducted to reveal that whether i.v. injection of oleuropein, the most potent polyphenolic antioxidant in olive leaf, has any effect on the magnitude of reperfusion arrhythmia in anesthetized rats or not. Methods: Eighty male Wistar rats were divided into 8 groups of 10 each: groups 1 and 5 were assigned as the prophylactic and treatment control groups, groups 2 and ...

In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...

Background: Oleuropein, the main constituent of olive fruit and leaves, has been reported to protect against insulin resistance and diabetes. While many experimental investigations have examined the mechanisms by which oleuropein improves insulin resistance and diabetes, much of these investigations have been carried out in either muscle cell lines or in vivo models two scenarios with many draw...

background: there is accumulating evidence that a polyphenol present in olive oil, oleuropein, has antioxidant, anti-inflammatory and anti-apoptotic effects. this study aimed at determining the anti-apoptotic effect of oleuropein (ole) on dexamethasone-induced apoptosis of mouse thymocytes. method: mice were randomly divided to four groups as follow: dexamethasone (dex)-treated group (20 mg/kg;...

BACKGROUND Oleuropein is known to have anti-oxidant and anti-inflammatory effects. An important aim of anesthetic management in ocular surgery is to keep the intraocular pressure under control. Studies have researched a variety of prophylactic materials used to prevent increases in intraocular pressure. We aimed to research the effects of oleuropein on intraocular pressure (IOP) during general ...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. there is accumulating evidence that oleuropein (oe) has anti-apoptotic effect. this study aimed at determining the dm toxicity and anti-apoptotic effect of oe pretreatment in cerebellar purkinje neurons. materials and methods: rats were randomly divided into four groups as f...

To understand the resistance of the olive tree to the leaf-spot disease caused by Spilocaea oleagina, the constitutive and postinfectional synthesis phenolic compounds of the leaves were analyzed by HPLC in 110 genotypes F1 (susceptible cultivar “Picholine marocaine” x resistant cultivar “Picholine du Languedoc”) presenting of the differential behaviours to this disease (highly resistant, resis...

Oleuropein contents (OLE) in leaves and fruits of from seven olive Syrian varieties harvested at spring and fall were determined by high-performance liquid chromatography. The results showed that, the concentration of OLE leaves samples measured in spring was higher than those determined in fall samples, where the OLE concentration in spring samples ranged between 5.6 9.2 mg/g. The highest conc...

The present study concerns the genotoxicity of olive mill waste water (OMWW) generated in mills producing olive oil in Morocco. The Vicia faba micronucleus test was used to evaluate the genotoxicity of OMWW and the six major phenolic compounds identified by HPLC in this effluent. Five dilutions of OMWW were tested: 0.1, 1, 5, 10 and 20%. Maleic hydrazide was used as a positive control. The resu...