Our studies using 3,4-dichlorobenzenethiol as a probe for methylating agent production during exposure of N-nitrosodimethylamine to rat liver S-9 preparations produced results different from those of an investigation reported in the literature. Methyl-3,4-dichlorophenyl thioether was detected, but the quantities found were not significantly different from the background levels of methylation pr...

A survey of boneless hams processed in elastic rubber nettings showed that 32 of 59 contained over 100 ppb Nnitrosodibenzylamine (NDBzA) on the surface. These findings demonstrated the need to reduce the nitrosamine content. Nettings made with rubber thread reformulated with zinc diisobutyldithiocarbamate vulcanizing agent were evaluated for their effect on reducing the nitrosamine content. The...

Abstract: Aim: To investigate chemo-preventive effect of methanolic fruit extract Cucumis melo var. agrestis on DEN (diethyl-nitrosamine) induced hepatocellular carcinoma in Sprague Dawley rats. Materials and Methods: Five groups rats randomly selected comprising 6 animals each group, all groups, except Group-1 were administered single dose (200 mg/kg, i.p. dissolved PBS) for the induction HCC ...

Mixed CO/NO-releasing molecules were prepared by conjugation of the 17-electron rhenium dicarbonyl cis-[Re(CO)2Br4](2-) complex to N-nitrosamine modified cyanocobalamin (B12) bio-vectors. The species were fully characterized by standard analytical techniques, including X-ray crystallography for cyanocobalamin-5'-O-pyrazine and () and its N-pyrazine nitrosylated derivative (). The N-nitrosamine ...

The unexpected finding of presence nitrosamine impurities, by USFDA and EMA in year 2018, drugs such as Angiotensin-II Receptor Blockers (ARBs), Ranitidine, Nizatidine Metformin, has triggered the need for a risk assessment strategy evaluation control these probable human carcinogen - pharmaceutical product that are at risk. This leads to voluntarily recall products worldwide. nitrosamines some...