نتایج جستجو برای: neurotoxins

تعداد نتایج: 3862  

Journal: :The Biochemical journal 2001
N Gong A Armugam P Mirtschin K Jeyaseelan

An Australian common brown snake, Pseudonaja textilis, is known to contain highly lethal neurotoxins. Among them, a long-chain alpha-neurotoxin, pseudonajatoxin b, has been identified. In this report, while presenting evidence for the presence of at least four such long-chain alpha-neurotoxins in the venom of P. textilis, we describe the characteristics of both the mRNA and the gene responsible...

Journal: :Pharmacology and Toxicology 2000

2015
Domenico Azarnia Tehran Giulia Zanetti Oneda Leka Florigio Lista Silvia Fillo Thomas Binz Clifford C. Shone Ornella Rossetto Cesare Montecucco Cristina Paradisi Andrea Mattarei Marco Pirazzini

Botulinum neurotoxins (BoNTs) form a large class of potent and deadly neurotoxins. Given their growing number, it is of paramount importance to discover novel inhibitors targeting common steps of their intoxication process. Recently, EGA was shown to inhibit the action of bacterial toxins and viruses exhibiting a pH-dependent translocation step in mammalian cells, by interfering with their entr...

2011
Nobuo TAMIYA Tatsuhiko YAGI

Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...

2001
A. L. Simonian E. N. Efremenko J. R. Wild

In order to develop a new strategy for the detection and discrimination of neurotoxins, the competing anti-acetylcholinesterase activities of mixtures of different neurotoxins were investigated. The combined inhibition effects in mixtures of organophosphates and carbamates (such as paraoxon/carbaryl, diisopropyl fluorophosphate (DFP)/carbaryl, paraoxon/DFP/carbaryl) were different than what was...

2017
Tatsuhiko YAGI Satoshi ŌMURA

Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...

2017
Tatsuhiko YAGI Satoshi ŌMURA

Erabutoxins a and b are neurotoxins isolated from venom of a sea snake Laticauda semifasciata (erabu-umihebi). Amino acid sequences of the toxins indicated that the toxins are members of a superfamily consisting of short and long neurotoxins and cytotoxins found in sea snakes and terrestrial snakes. The short neurotoxins to which erabutoxins belong act by blocking the nicotinic acetylcholine re...

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