To ensure targeting of apoferritin nanocarrier with encapsulated doxorubicin drug, we used a peptide linker based on a protein G with N-terminus affinity towards Fc region of antibodies. To connect the peptide to the surface of apoferritin, the C-terminus of peptide was made of cysteine with affinity to gold. The surface of apoferritin with encapsulated doxorubicin (APODOX) was coated either wi...

Taste is the most crucial organoleptic parameter affecting patient compliance in case of drugs with poor palatability. masking a major challenge for development orally ingested active pharmaceutical constituents industry. Numerous conventional taste-masking techniques have been extensively studied. In parallel, drug solubility or release concern techniques. Recently, many nanocarrier systems in...

the objective of the present study was to investigate the role of nanocarrier of magnetic isotope of 25-mg2+ (pmc16) in liver toxicity, atp content and oxidative stress due to malathion (mal) exposure. pmc16 nanoparticle were administered in different doses (0.05, 0.1 and 0.2 ld50) intravenously (iv) 40 minutes after a single mal (0.25 ld50= 207 mg/kg) intraperitoneal (ip) injection as a comple...

We developed a novel active nanocarrier of common antibiotics, which can efficiently degrade biofilms resistant bacteria and bypass their defences.

We report novel insights into treating mould with nanocarrier-loaded antimould agents Ziram and IPBC explore the effects of surface coating method delivery.

Dendrimers and telodendrimer micelles represent two new classes of vehicles for drug delivery that have attracted much attention recently. Their structural characterization at the molecular and submolecular level remains a challenge due to the difficulties in reaching high resolution when imaging small particles in their native media. This investigation offers a new approach towards this challe...

The efficient delivery of nanocarrier-based cancer therapeutics into tumor tissue is problematic. Structural abnormalities, tumor vasculature heterogeneity, and elevated intratumor pressure impose barriers against the preferential accumulation of nanocarrier-based cancer therapeutics within tumor tissues and, consequently, compromise their therapeutic efficacy. Recently, we have reported that m...

Cancer is a major health problem in the world. Advances made in cancer therapy have improved the survival of patients in certain types of cancer. However, the overall five-year survival has not significantly improved in the majority of cancer types. Major challenges encountered in having effective cancer therapy are development of drug resistance by the tumor cells, nonspecific cytotoxicity, an...

Since the first report of the enhanced permeability and retention (EPR) effect, the research in nanocarrier based antitumor drugs has been intense. The field has been devoted to treatment of cancer by exploiting EPR-based accumulation of nanocarriers in solid tumors, which for many years was considered to be a ubiquitous phenomenon. However, the understanding of differences in the EPR-effect be...