Acute necrotizing pancreatitis (ANP) is associated with significantlyhighermorbidity and mortality. It still difficult for the surgeon to choose schedule most appropriate treatment.In early phase of disease, surgical activity considered be ineffective high risks. The only chance save patient conduct intensive therapy in care unit, based on current pathogenetic approaches. present review analyze...

Background: The use of β-blockers during the perioperative period remains controversial. Although some studies have demonstrated their protective effects regarding postoperative cardiac complications, others have demonstrated increased mortality when β-blockers were introduced before surgery. Methods: In this observational study involving 1,801 patients undergoing aortic reconstruction, we pros...

Cilia are highly conserved organelles that have diverse motility and sensory functions. Recent discoveries have revealed that cilia also have crucial roles in cell signaling pathways and in maintaining cellular homeostasis. As such, defects in cilia formation or function have profound effects on the development of body pattern and the physiology of multiple organ systems. By categorizing syndro...

The pathophysiological effects of severe sepsis, septic shock and related syndromes result from tissues damaged by the uncontrolled production of the mediators of inflammation. Early deaths are related primarily to the acute effects of the systemic inflammatory response. Later deaths are related more closely to the consequences of multiple organ dysfunction. Monoclonal antibodies and other immu...

This article provides an overview of the complex relationship between inflammation and coagulation and a review of routinely available laboratory and point-of-care tests for the detection of inflammation and coagulopathies. In the management of cases requiring ongoing laboratory and clinical evaluation, examination of these two major pathologic processes may assist with diagnosis and improve ou...