نتایج جستجو برای: mpt
تعداد نتایج: 1014 فیلتر نتایج به سال:
Mitochondrial permeability transition (MPT) has been proposed to play a key role in cell death. Downstream MPT events include the release of apoptogenic factors that sets in motion the mitochondrial apoptosome leading to caspase activation. The current work examined the regulation of MPT by membrane fluidity modulated upon cholesterol enrichment. Mitochondria enriched in cholesterol displayed i...
We studied the interplay between matrix Ca(2+) concentration ([Ca(2+)]) and mitochondrial membrane potential (Deltapsi) in regulation of the mitochondrial permeability transition (MPT) during anoxia and reoxygenation. Without Ca(2+) loading, anoxia caused near-synchronous Deltapsi dissipation, mitochondrial Ca(2+) efflux, and matrix volume shrinkage when a critically low PO(2) was reached, whic...
Palmitoyl-CoA (Pal-CoA) lowered the respiratory control ratio (RCR), and induced mitochondrial membrane permeability transition (MPT) and cytochrome c (Cyt. c) release from isolated rat liver mitochondria. L-Carnitine suppressed the Pal-CoA-induced dysfunction, MPT, and Cyt. c release of isolated mitochondria. This suppression was inhibited by cephaloridine, an inhibitor of carnitine uptake int...
The initial analysis of the oral combination melphalan, prednisone, and thalidomide (MPT) in newly diagnosed patients with myeloma showed significantly higher response rate and longer progression-free survival (PFS) than did the standard melphalan and prednisone (MP) combination and suggested a survival advantage. In this updated analysis, efficacy and safety end points were updated. Patients w...
A graph G is a max point-tolerance (MPT) graph if each vertex v of G can be mapped to a pointed-interval (Iv, pv) where Iv is an interval of R and pv ∈ Iv such that uv is an edge of G iff Iu ∩ Iv ⊇ {pu, pv}. MPT graphs model relationships among DNA fragments in genome-wide association studies as well as basic transmission problems in telecommunications. We formally introduce this graph class, c...
Multinomial processing tree (MPT) modeling has been widely and successfully applied as a statistical methodology for measuring hypothesized latent cognitive processes in selected experimental paradigms. In this article, we address the problem of selecting the best MPT model from a set of scientifically plausible MPT models, given observed data. We introduce a minimum description length (MDL) ba...
Development of the mitochondrial permeability transition (MPT) can importantly contribute to lethal cell injury from both necrosis and apoptosis, but its role varies considerably with both the type of cell and type of injury, and it can be strongly opposed by the normally abundant endogenous metabolites ADP and Mg(2+). To better characterize the MPT in kidney proximal tubule cells and assess it...
BACKGROUND Maximum phonation times (MPT) of vowels in adult women with vocal nodules. AIM To verify and to correlate the values of MPT of vowels in young and middle-aged adult women with vocal nodules. METHOD Database records from a speech therapy school-clinic were used, making up a total of 38 subjects. INCLUSION CRITERIA female adults, aged between 20 and 53 years, with otorhinolaryngo...
Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial permeability transition (MPT). MPT is caused by the opening of permeability transit...
Mitochondrial matrix cyclophilin D (CyPD) is known to promote development of the mitochondrial permeability transition (MPT). Kidney proximal tubule cells are especially prone to deleterious effects of mitochondrial damage because of their dependence on oxidative mitochondrial metabolism for ATP production. To clarify the role of CyPD and the MPT in proximal tubule injury during ischemia-reperf...
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