Objectives The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long-term impact steroid irrigations (SIs) on quality life patients ESBS. Methods Retrospective review at the University Pennsylvania undergoing ESBS from 2010 2019. Data patient demographics and treatment with nasal saline ...

Introduction With emerging cases of adrenal suppression being reported in pediatric patients, finding appropriate steroid sparing agents is of clinical importance. Tiotropium bromide (TB), a long-acting anticholinergic, has recently been investigated in adults as a steroid-sparing agent in asthma step-up therapy. We report the first case of tiotropium bromide (TB) used as a step-up steroid spar...

PURPOSE OF REVIEW The purpose of this review is to compare and contrast the newer inhaled corticosteroid (ICS) ciclesonide with older ICSs in terms of pharmacodynamic and pharmacokinetic properties and how these affect comparative efficacy. In addition, clinical dosing strategies for ICSs including as-needed use will be explored. RECENT FINDINGS Ciclesonide has demonstrated similar efficacy t...

Psoriasis is a common skin disorder that may be triggered by hormonal disturbances, among other factors. Some studies have demonstrated an elevation of serum parathyroid hormone (PTH) levels in psoriasis and several other diseases of keratinization of unknown aetiology. PTH-related peptide (PTH-rp), on the other hand, is a potent inhibitor of epidermal cell growth factor and is not expressed in...

• Allergic rhinitis is defined as intermittent (or seasonal) or persistent (or perennial), according to symptom duration and frequency. • Intranasal corticosteroids are the most effective treatment option for moderate-severe symptoms and reduce sneezing, rhinorrhea, itching, post-nasal drip and nasal blockage, and total nasal symptom scores better than antihistamines. • There are currently six ...

Circumcision is traditionally performed for persistent phimosis in boys. Although there continues to be a considerable debate over the merits of circumcision, it is clear that preservation of the pediatric foreskin even in the presence of phimosis is a viable option. Prepuce spontaneously separates from the glans as the age increases and true phimosis is rare in children(1). Prepuce develops an...

Inhaled corticosteroids (ICS) have proven to be the most effective and essential therapy for the treatment of bronchial asthma. The 2007 National Asthma Education and Prevention Program guidelines recommend ICS as preferred therapy for patients with mild to severe persistent asthma. Mometasone furoate (MF) is a relatively new ICS agent with high affinity for the glucocorticoid receptor. It is a...

OBJECTIVE Inadequate asthma control may affect asthma resource use and treatment charges, consequently contributing to the growing economic burden of asthma. The study objective was to determine the impact of medication adherence and asthma control on resource use and charges in mild asthmatic patients treated with inhaled corticosteroids (ICSs). RESEARCH DESIGN AND METHODS A claims database ...

1 Chrousos GP, Ghaly L, Shedden A, et al. Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects. Chest 2005; 128:70–77 2 Le Souef P. The meaning of lung dose. Allergy 1999; 54(suppl 49):93–96 3 Leach CL, Davidson PJ, Hasselquist BE, et al. Lung deposition of hydro...