1. Post Graduate Student, Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad. 2. Reader, Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad 3. Senior Lecturer, Department of Oral Pathology and Microbiology, Teerthanker Mahaveer Dental College & Research Centre, Moradabad 4. ...

This paper considers studies aimed at identifying markers of genotoxicity (chromosomal aberrations, micronuclei, and DNA damage assessed by the comet assay) in patients with both gestational diabetes mellitus (GDM) type 1 2 (T1DM T2DM, respectively), as well possible changes levels these genotoxic under influence medicines nutritions. Patients T2DM are characterized an increased level markers. ...

AIM To describe the cohort of Croatian workers monitored for micronuclei in peripheral blood lymphocytes and validate predictive value of micronuclei for the risk of cancer development. METHODS Between 1985 and 1999, peripheral blood lymphocytes were analyzed with in vitro micronucleus assay in a cohort of 200 subjects occupationally exposed to genotoxic agents. The follow-up for cancer incid...

The micronucleus and nuclear abnormalities assays have been used increasingly to evaluate genotoxicity of many compounds in polluted aquatic ecossystems. The aim of this study is to verify the efficiency of the micronucleus assay and nuclear abnormality assay in field and laboratory work, when using erythrocytes of the tropical marine fish Bathygobius soporator as genotoxicity biomarkers. Gill ...

Biological monitoring of early genotoxic effects in urothelial cells using the urinary micronucleus (MNu) assay is promising for early detection of cancer, such as bladder carcinoma. But many problems are encountered, the major being the poorly differential staining of cells, particularly in women having an important amount of squamous cells. We have optimized the protocol and obtained a differ...

BACKGROUND The Amazon represents an area of 61% of Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance of agribusiness. Composition of the atmosphere is controlled by several natural and anthropogenic processes, and emission from biomass burning is one with the major impact on human health. The aim of this study was to evalu...

Background: Most of the cytogene c dosimetry, except Premature Chromosome Condensa on assay, saturates at 6 Gy. Present studies are aimed to assess feasibility of simple CB‐MN assay for prescreening of high dose accidental exposures. Materials and Methods: Human peripheral blood lymphocytes from two donors were gamma irradiated to different doses ranging from 0‐15Gy, cultured for 72 h. Cytochal...

AIM To estimate genome damage in oropharyngeal cancer patients before, during, and after radiotherapy and to measure the persistence of caused genome damage relevant in the evaluation of secondary cancer risk. METHODS DNA damage was evaluated in peripheral blood lymphocytes of 10 oropharyngeal cancer patients using alkaline comet assay, analysis of structural chromosome aberrations, and micro...

Pesticides are considered to be one of the biggest economic and ecological problems in aquatic ecosystem. Monitoring for toxic effects screening different insecticides is vital crucial reducing adverse on organisms public health. Therefore, this study, we aimed determine genotoxic effect acetamipridine a model fish species, Cyprinus carpio, using micronucleus test Comet assay. Common carp (aver...

The purpose of the present study was to determine the effect of a single oral dose of carbendazim (CARB) on the frequencies of numerical chromosome aberrations in sperm and on micronuclei in peripheral blood erythrocytes of rats. Dual colour FISH on epididymal sperm of rats treated 31 days before sacrifice (0, 50, 150, 450 and 800 mg/kg body wt CARB in corn oil), corresponding to exposure durin...