J.D. Bernhard, MD, Division of Dermatology, University of Massachusetts Medical Center, Worcester, MA 01655 (USA) Dear Sir The picture of ‘brownish macules showing a rippled surface’ on the back of the patient with cutaneous amyloidosis reported by Barnadas et al. [1] is striking because the appearance, location and long history of localized pruritus are virtually identical to what is seen in n...

Lichen simplex (LS) is characterized by circumscribed, lichenified, pruritic patches that may develop on any part of the body. Macular amyloidosis (MA) is the form of primary localized cutaneous amyloidosis. Transcutaneous electrical nerve stimulation (TENS) uses a pulsed electric current generated transcutaneously by a device to cause impulses to be carried along large-diameter afferent nerves...

systemic amyloidosis is a very rare complication of inflammatory bowel disease (ibd). the reported cases of secondary amyloidosis in children with ibd are much fewer than those reported in adults. herein, a teenage boy with crohn’s disease is presented who developed nephrotic syndrome due to renal involvement secondary to amyloidosis, whereas the patient was under treatment with corticosteroid ...

Wrinkling was seen in 191 (95.5%) of cases. Most of the wrinkling was in the form of glyphic wrinkles on sun-exposed areas viz. face, neck, forearms and dorsa of hands. Generalized pruritus was present in 37 patients (18.5%) and psoriasis in 25 (12.5%). Fungal infection was the most common infection (70, 35%), followed by viral infections (10, 5%), pyodermas (4, 2%) and leprosy (3, 1.5%). Macul...

BACKGROUND AND OBJECTIVES The kidney is the organ most commonly involved in systemic amyloidosis. This study reports the largest clinicopathologic series of renal amyloidosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This study provides characteristics of 474 renal amyloidosis cases evaluated at the Mayo Clinic Renal Pathology Laboratory from 2007 to 2011, including age, sex, serum creat...

Hyperimmunization of horses with specific antigens to harvest antisera is associated with high incidence of liver amyloidosis. The histopathologic examination is the gold standard method for diagnosis of the hepatic amyloidosis. The aim of the present study was to determine whether the clinical manifestations and serum values of appropriate chemical constituents due to liver injury, provide the...

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An 80-year-old Caucasian female patient presented with a two-year history of intensively itching skin rash located on her left lower leg and mild swelling of the proximal interphalangeal and metacarpophalangeal joints, accompanied by morning stiffness around these joints, lasting at least one hour before maximal improvement (Figures 1A and 1B). She reported having had a long-lasting medical his...

 Background: Diabetes is a common metabolic disorder leading to the development of many complications, among which diabetic retinopathy and macular edema are the most significant. These complications can contribute to blindness if not diagnosed or treated properly, and several studies have been conducted to evaluate the methods for the prevention or slowing down their progression. Ther...