Background & AimsThe circadian rhythms play significant roles in immune responses and many inflammatory processes liver diseases are associated with malfunctioning molecular clocks. However, the significance of clock autoimmune hepatitis (AIH) which is characterized by immune-mediated hepatocyte destruction extensive cytokine production remains unclear.MethodsWe tested difference susceptibility...

Background Macrophages are considered an essential source of inflammatory cytokines, which play a pivotal role in the development diabetes and its sequent complications. Therefore, better understanding intersection between macrophage is massive importance. Objectives In this study, we performed informative bibliometric analysis to enlighten relevant research directions, provide valuable metrics...

Tumor-associated macrophages are able to regulate the tumor cell proliferation and affect dissemination. The study was aimed assess predictive potential of macrophage population immunohistochemical phenotyping in early malignization H. pylori-associated chronic gastritis. Gastic biopsy samples male female patients aged 48 ± 7.2 infected with Helicobacter pylori were used as research material. d...

Macrophage ATP-binding cassette transporter A1 (ABCA1), scavenger receptor class B type I (SR-BI), and ABCG1 have been shown to promote cholesterol efflux to extracellular acceptors in vitro and influence atherosclerosis in mice, but their roles in mediating reverse cholesterol transport (RCT) from macrophages in vivo are unknown. Using an assay of macrophage RCT in mice, we found that primary ...

Background: C5areceptor antagonistPMX205 is a synthetic hexapeptidecapable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a myriad inflammation models. The anti-inflammatory effect of PMX205 on periodontitis is yet to be fully fathomed. Objective: To examine the anti-inflammatory effec...

Liver ischemia and reperfusion (IR) injury is the major complication of liver-related operations. Macrophage polarization has an essential effect on mechanism liver IR injury. Vitamin D receptor (VDR) been found to regulate macrophage alleviate Nevertheless, correlation between VDR in not clearly elucidated. knockout mice wild-type littermates underwent partial for 90 min 6 h. RAW264.7 cells we...