The current investigation was used to improve the rate of dissolution an anti-diarrheal drug i.e., racecadotril (RT) at low pH conditions (i.e., in stomach) by reducing water secretion and electrolyte intestine liquisolid tablets. Different formulations (liquisolid) were prepared using Avicel PH 102 as a carrier. Aerosil 200 coating material sodium starch glycolate disintegrant. Polyethylene gl...

Liquisolid systems are a novel, promising platform for the production of solid dosage forms with high liquid content, i.e. dispersion drug in suitable, hydrophilic, non-volatile vehicle or drug. This technology requires conventional, but highly porous excipients (carrier and coating material appropriate ratio) able to absorb/adsorb medication, resulting both good flowability acceptable compress...

The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin (IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable polysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial degradable polysaccharides were ...

The objective of the present work was to obtain pH independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisolid compacts were prepared using Transcutol HP as vehicle, Avicel PH102 as carrier, and Aerosil 200 as a coating material. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow pr...

Objective: The current research is aimed to enhance the dissolution and bioavailability of Palbociclib by formulating into solid dispersion Methods: dispersions (SD) prepared adopting different methods: Surface technique (SSD1-SSD15), Melt granulation (MG1-MG15) Liquisolid compacts (LSC1-LSC9). All formulations were evaluated for physico-chemical parameters followed in vitro studies. optimised ...