نتایج جستجو برای: lipase gene

تعداد نتایج: 1154330  

Journal: :Nihon rinsho. Japanese journal of clinical medicine 1995
A Tanaka

Wolman disease and cholesteryl ester storage disease (CESD) are caused by a deficiency of lysosomal acid lipase activity, resulting in massive accumulation of cholesteryl ester and triglycerides. Wolman disease occurs in infancy, with hepatosplenomegaly, steatorrhea and adrenal calcification. It is fatal before the age of 1 year. In CESD, hepatomegaly may be the only clinical abnormality, altho...

A.R Bandegi M Firoozray M.R Akbari-Eydgahi

Background & Aims: Lipoprotein lipase (LPL) is one of the key enzymes regulating the metabolism of triglycerides (TG) and HDL cholesterol. The lipoprotein lipase (LPL) gene polymorphisms are possibly involved in the pathophysiology of dyslipidemia. Hind III polymorphism is one of the most common polymorphisms in LPL gene. In some studies, association of Hind III polymorphism with dyslipidemia h...

Journal: :Applied and environmental microbiology 1995
X Li S Tetling U K Winkler K E Jaeger M J Benedik

The gene encoding extracellular lipase of Serratia marcescens has been identified from a phage lambda genomic library. Formation of orange-red fluorescent plaques on rhodamine B-triolein plates was used to identify phages carrying the lipase gene. A 2.8-kb SalI fragment was subcloned into a plasmid, and lipase was expressed in Escherichia coli. Extracellular lipase was detected in the presence ...

Genetic hyperchylomicronemia is a rare autosomal recessive disorder of lipoprotein metabolism estimated to affect approximately one per million individuals. We report a case with a rare mutation identified. It’s a genetic chylomicronemia in a Moroccan newborn baby, with massive hypertriglyceridemia and clinical signs of acute pancreatitis. She was a newborn female, first-degree of consanguineou...

Journal: :journal of agricultural science and technology 2015
n. monfared m. yazdanpanah k. tavakoli

the aim of this study was to investigate the effect of the addition of commercial lipase in various forms on the acceleration of the ripening of uf-feta cheese. commercial lipase from aspergillus niger was encapsulated by using silica composition based on sol-gel method. lipase was then added to cheeses in three forms, namely, free lipase, encapsulated lipase, and encapsulated lipase with arabi...

Journal: :Circulation 1998
S M Grundy G J Balady M H Criqui G Fletcher P Greenland L F Hiratzka N Houston-Miller P Kris-Etherton H M Krumholz J LaRosa I S Ockene T A Pearson J Reed R Washington S C Smith

1. Cholesterol management in high-risk patients without heart disease. When is lipid-lowering medication warranted for primary prevention? Grundy SM. 3. The role of cholesterol management in coronary disease risk reduction in elderly patients. [PubMed-indexed for MEDLINE]Related citations 4. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found ...

2013
Ziyun Wang Shen Li Lidan Sun Jianglin Fan Zhenming Liu

The triglyceride lipase gene subfamily plays a central role in lipid and lipoprotein metabolism. There are three members of this subfamily: lipoprotein lipase, hepatic lipase, and endothelial lipase. Although these lipases are implicated in the pathophysiology of hyperlipidemia and atherosclerosis, their structures have not been fully solved. In the current study, we established homology models...

2012
Farshad Darvishi

Saccharomyces cerevisiae cannot produce extracellular lipase and utilize low-cost lipid substrates. This study aimed to express extracellular lipase from Yarrowia lipolytica in S. cerevisiae, construct recombinant oily substrate consumer strains, and compare the roles of native and mutant Y. lipolytica extracellular lipases in S. cerevisiae. The LIP2 gene of Y. lipolytica DSM3286 and its mutant...

Journal: :Journal of general microbiology 1993
A M Farrell T J Foster K T Holland

Lipase of Staphylococcus epidermidis 9 was purified from culture supernatant fluid. Two polypeptides (51 and 43 kDa) were detected by SDS-PAGE, of which the 43 kDa polypeptide reacted with anti-lipase serum. The S. epidermidis 9 lipase gene (gehC) was cloned in Escherichia coli and localized to a 2.1 kb sequence by subcloning and transposon mutagenesis. The nucleotide sequence of gehC (2064 nuc...

Journal: :Human molecular genetics 2003
Xiao-Yan Wen Robert A Hegele Jian Wang Ding Yan Wang Joseph Cheung Michael Wilson Maryam Yahyapour Yahong Bai Lihua Zhuang Jennifer Skaug T Kue Young Philip W Connelly Ben F Koop Lap-Chee Tsui A Keith Stewart

Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating evidence suggests an independent association between plasma TG concentration and increased atherosclerosis risk. We previously generated a mouse insertional mutation lpd (lipid defect) whose phenotype included elevated plasma TG and hepatic steatosis. Using shotgun sequencing (approximately 500 ...

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