Background: Pain is a both sensory and an emotional experience when untreated unrecognized, it extracts significant physiological, biochemical psychological toll on the children family members. Vaccine injections are considered to be most common cause of iatrogenic pain in childhood. Positive during vaccine injection like reducing with local anaesthetics can avoid pre procedural anxiety future,...

Lv et al.1 present a newly designed disposable circumcision device. The device cuts the foreskin and closes the skin edges with staples simultaneously. Their results suggest a fast operating time, low complication rate, and high patient satisfaction. This device is easy to operate and can be used with local anesthesia alone. In an age when several African countries consider mass circumcision to...

Premature ejaculation (PE) is the most common sexual problem affecting men. It can affect men at all ages and has a serious impact on the quality of life for men and their partners. Currently there are no pharmaceutical agents approved for use in the UK, and so all drugs used for this condition are off label. Behavioral therapy has been used to treat PE, but the results are not durable once the...

This study compared pain on application, pain on venipuncture, cost, and convenience of 4 analgesic agents used for venipuncture. A convenience sample of 280 preoperative subjects was assigned randomly to 1 of 4 groups. Group 1 received 2.5% lidocaine--2.5% prilocaine cream (LPC) topically, Group 2 received dichlorotetrafluoroethane spray (DCTF), Group 3 received 0.5% lidocaine subcutaneously, ...

Herpes zoster is a relapse of varicella. In certain cases, long-term pain and hyperhidrosis have been noted. Appearance of herpes zoster during pregnancy is infrequent. We described hyperhidrosis and pain treatment using glycopirrolate cream in a pregnant woman with herpetic neuralgia. A 32 year old woman, 21 weeks pregnant with second child, complained to her gynecologist of the appearance of ...

We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especi...

the forced degradation study of lidocaine hcl was carried out according to the ich guideline q1a (r2). the degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by gc-fid method and nuclear magnetic resonance (nmr) spectroscopy. according to these results, the degradation products were not obse...

conclusions this study does not support the use of emla for hsg. results there was no significant difference in the efficacy between emla and placebo creams in pain perception during the entire procedure. there was no significant difference in long term pain perception half an hour after the hsg performance. patients and methods eighty patients undergoing hsg as part of infertility evaluation w...