This study was designed to evaluate possible organ and system disorders associated with experimentally induced levamisole poisoning in dogs. For this purpose, twelve clinically healthy dogs of different ages, sexes and breeds were used. They were divided into two equal groups (Group A and Group B) and given levamisole orally at a dose of 25 mg/kg of body weight daily for three days. The dogs in...

Levamisole is an antihelminthic agent used mainly by veterinarians that is now commonly used as an adulterant in cocaine [1]. Numerous case reports have connected levamisole with vasculitis and neutropenia [2, 3]. Our case focuses on a patient who used weekly cocaine contaminated with levamisole and developed necrosis of the skin in her lower extremities, abdomen, and lower back. To our knowled...

Abstract Levamisole is an anthelminthic that was first used as a de-worming agent in humans and animals. It has also been used to treat inflammatory conditions as well as certain types of cancer. Levamisole was discontinued for human use in the early 21st century due to toxic side effects including agranulocytosis and vasculitis. Recently, levamisole was discovered as a cocaine adulterant after...

This study was undertaken to evaluate the influence of levamisole on the immune enhancement of Nile tilapia (Oreochromis niloticus) against potential bacterial pathogens, Fish with weight of 98±5 g were randomly distributed into seven groups each at a rate of 20 fish per 300-L aquarium and fed on a diet containing 0.0, 250, 500, 750, 1000, 1250 or 1500 mg levamisole/kg diet for eight weeks. Aft...

levamisole is one of the anti-parasitic drugs that widely used in veterinary and aquatic animal medicine. previous investigation showed that levamisole has some stimulatory effect on immunity and liver metabolism. in this investigation effect of levamisole on cholesterol, triglycerol and lipoproteins as metabolic activity indicator has been studied. for this purpose 120 common carp randomly div...

background hepatitis b virus (hbv) infection is much more common in hemodialysis patients than the general population. these patients have an impaired immune response to hbv vaccination; to that end there are certain studies that have evaluated levamisole as an immunomodulator agent improving hbv vaccination response rate in hemodialysis patients. objectives in the current review, we have assem...

Angioedema is an intense often disfiguring but temporary swelling of a localized area which usually involves superficially lying structures like skin, mucosa along with subcutaneous tissues. Areas are affected by angioedema have wide range starting from the face, lips, tongue, pharynx, supraglottic and rarely, subglottic area. It might also effect gastrointestinal mucous membranes, genitalia, h...

The effect of Levamisole was studied in an animal model of Wilms’ tumor. No tumoridical effect of Levamisole could be documented in this tumor model, and no effect was shown on prevention of tumor, when Levamisole was given before tumor implantation. In previous experience with Wilms’ tumor model, a good correlation between the human and animal tumor was found in regard to treatment with differ...

There are many reports that show the teratogenic effects of phenobarbital can be decreased by stimulation of maternal immune system. Therefore, in this study, the prophylactic effects of levamisole and vitamin E on teratogenic effects of phenobarbital were compared. This study was performed on 20 pregnant rats that were divided into four groups. Control group received normal saline and test gro...

Exposure to levamisole-adulterated cocaine can induce a distinct clinical syndrome characterized by retiform purpura and/or agranulocytosis accompanied by an unusual constellation of serologic abnormalities including antiphospholipid antibodies, lupus anticoagulants, and very high titers of antineutrophil cytoplasmic antibodies. Two recent case reports suggest that levamisole-adulterated cocain...