Leser-Trélat sign is characterized by the sudden onset and rapid growth in number and size of multiple seborrheic keratoses, in relation to an underlying neoplasm. It is sometimes accompanied by pruritus and often associated with acanthosis nigricans. We describe a 63-year-old man diagnosed with plaque-stage mycosis fungoides who, during phototherapy, developed severe erythema and generalized s...

The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Although these dermatoses are relatively unusual, the recognition of some typical paraneoplastic dermatoses may lead to the early diagnosis of a neoplasm and determine a better prognosis. In this review article, we discuss the paraneoplastic cutaneous manif...