نتایج جستجو برای: l1 pre
تعداد نتایج: 343074 فیلتر نتایج به سال:
Nucleolin is one of the most abundant protein in the nucleolus and is a multifunctional protein involved in different steps of ribosome biogenesis. In contrast to animals and yeast, the genome of the model plant Arabidopsis thaliana encodes two nucleolin-like proteins, AtNUC-L1 and AtNUC-L2. However, only the AtNUC-L1 gene is ubiquitously expressed in normal growth conditions. Disruption of thi...
Even with recent advances in therapy regimen, multiple myeloma patients commonly develop drug resistance and relapse. The relevance of targeting the PD-1/PD-L1 axis has been demonstrated in pre-clinical models. Monotherapy with PD-1 inhibitors produced disappointing results, but combinations with other drugs used in the treatment of multiple myeloma seemed promising, and clinical trials are ong...
مقدمه: عوامل متعددی در بروز ناباروری مردان موثر می باشد که ازآن جمله می توان به عفونت های تناسلی اشاره نمود. عفونت های تناسلی می توانند در اثر آلودگی های میکروبی، قارچی و ویروسی به وجود آیند. اخیرا تحقیقات مختلفی، در رابطه با عفونت پاپیلوماویروس و تاثیر آن بر پارامترهای عملکردی اسپرم از جمله حرکت، مورفولوژی، تعداد اسپرم ها و کاهش قدرت باروری مردان صورت گرفته است ولی ارتباط بین عفونت پاپیلوما وی...
BACKGROUND Characteristics of tumor microenvironment have been suggested as predictive markers of anti-EGFR or anti-HER2 treatment response. However, the effect of EGFR/HER2 signal blockade on the tumor immune microenvironment is unclear. METHODS EGFR/HER2 pathway signaling and PD-L1 expression in gastric cancer cell lines were screened by western blot analysis. PD-L1 and HER2 expressions in ...
Guillardia theta anion channelrhodopsin 1 (GtACR1) is a widely used inhibitor of optogenetics with unique conductance mechanisms and photochemistry. However, the molecular mechanism light-gated conduction poorly understood without crystal structure for intermediate state. In this study, we built dark-state model based on retinal isomerized by twisting C12-C13=C14-C15 dihedral step using dynamic...
The immunomodulatory receptor TIGIT (T-cell Immunoreceptor with Ig and ITIM domains) is a novel inhibitory immune checkpoint on activated T cells natural killer in multiple cancers. Tiragolumab (tira) humanized IgG1/kappa monoclonal antibody that binds to prevent its interaction ligand PVR (CD155). Because PD-L1 expression considered hallmark of pre-existing immunity positively correlated expre...
This qualitative study investigated teachers’ perspectives on the functions of first language (L1) use in second (L2) classroom. Data were collected from seven Jordanian English as foreign (EFL) teachers, where each teacher participated one classroom observation and two rounds interviews, pre-observation post-observation. Interviews transcribed coded for recurrent themes. Thematic analysis iden...
Patients with high-grade serous ovarian carcinoma (HGSOC) gradually acquire resistance to standard chemotherapy after recurrence. In our previous study of HGSOC, histone deacetylase (HDAC)6 upregulation led poor prognosis, and programmed cell death ligand-1(PD-L1) expressions positively correlated HDAC6 expression. We analyzed the expression PD-L1 pre- post-chemotherapy investigate their associ...
Adipose tissues were shown to host Mycobacterium tuberculosis which is persisting inside mature adipocytes. It remains unknown whether this holds true for Mycobacterium canettii, a rare representative of the M. tuberculosis complex responsible for lymphatic and pulmonary tuberculosis. Here, we infected primary murine white and brown pre-adipocytes and murine 3T3-L1 pre-adipocytes and mature adi...
It is a widely adopted practice for firms to announce new products well in advance of actual market availability, especially in the computer industry. In this paper, a firm makes pre-announcements on its product, which are ‘cheap talk.’ We develop a reputation model of vaporware where the product pre-announcement can convey information about the product’s quality. Also, we discuss its implicati...
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