Potassium channels represent the dominant ion conductance of vascular smooth muscle cell membranes and play a major role in the regulation of membrane potential (18,19). Membrane potential, in turn, regulates the open state probability of voltage-gated Ca channels (18,19). Thus, as illustrated in Fig. 1, the closure of K channels and the loss of outward K current lead to depolarization, opening...

royan b 1 stem cell can be differentiated to specialized cell types including cardiomyocytes. this developmental change is accompanied with expression of various k + channel types. the aim of this study was to detect functional expression of k + currents from stem cell stage and one week and two weeks after differentiation into cardiomyocyte. mouse stem cell derived cardiomyocytes (es-cardiomyo...

Introduction: It has recently been suggested that the KATP channel subunits Kir6.x and BKCa channels exist in the endoplasmic reticulum of cardiomyocytes and neurons. Our previous studies showed the electrophysiological behavior of cation channels in the rough endoplasmic reticulum (RER) of rat hepatocytes. Therefore, we hypothesized that KATP channels and Ca2+-activated potassium channels m...

Calcium-activated potassium (K(Ca)) channels are present throughout the central nervous system as well as many peripheral tissues. Activation of K(Ca) channels contribute to maintenance of the neuronal membrane potential and was shown to underlie the afterhyperpolarization (AHP) that regulates action potential firing and limits the firing frequency of repetitive action potentials. Different sub...