BACKGROUND & AIMS In the last decade, pegylated interferon-α (PegIFN-α) plus ribavirin (RBV) was the standard treatment of chronic hepatitis C for genotype 1, and it remains the standard for genotypes 2 and 3. Recent studies reported associations between RBV-induced anemia and genetic polymorphisms of concentrative nucleoside transporters such as CNT3 (encoded by SLC28A3) and inosine triphospha...

abstract: a pure nucleotide pool is an essential precursor of correct dna replication and prevention of mutagenesis and abnormality in a living cell. inosine triphosphatase (itpase) is a critical enzyme to remove any deaminated rough purine nucleotides such as inosine from nucleotide pool. it has been shown that the rate of substitution mutation in genomic dna increase by abnormal function and ...

REFERENCES 1 Harari S, Caminati A. Pulmonary Langerhans’ cell histiocytosis. Eur Respir Mon 2009; 46: 155–175. 2 Weinshilboum R, Wang L. Pharmacogenomics: bench to bedside. Nat Rev Drug Discov 2004; 3: 739–748. 3 Bakker JA, Bierau J, Drent M. Therapeutic regimens in interstitial lung disease guided by genetic screening: fact or fiction?Eur Respir J 2007; 30: 821–822. 4 Coulthard S, Hogarth L. T...

OBJECTIVE To examine the effects of a computer-assisted, interactive tailored patient assessment (ITPA) tool in oncology practice on: documented patient care, symptom distress, and patients' need for symptom management support during treatment and rehabilitation. DESIGN AND METHODS For this repeated measures clinical trial at a university hospital in Norway, 145 patients starting treatment fo...

Nucleotide quality surveillance enzymes play important roles in human health, by detecting damaged molecules in the nucleotide pool and deactivating them before they are incorporated into chromosomal DNA or adversely affect metabolism. In particular, deamination of adenine moiety in (deoxy)nucleoside triphosphates, resulting in formation of (d)ITP, can be deleterious, leading to DNA damage, mut...

Inosine triphosphatase (ITPA) single nucleotide polymorphisms (SNPs) are strongly associated with protection against ribavirin (RBV)-induced anaemia in European, American and Asian patients; however, there is a paucity of data for Brazilian patients. The aim of this study was to evaluate the ITPA SNP (rs7270101/rs1127354) frequency in healthy and hepatitis C virus (HCV)-infected patients from B...

Background: spastic diplegic cerebral palsy (D-CP) is frequently related to periventricular leukomalacia (PVL), which usually affects the descending motor fibers of the association cortex and association fibers of the visual, auditory and somesthesic functions. Aim: to verify the performance of children with D-CP regarding their psycholinguistic skills. Method: participants were eight individua...

The objective of this study was to investigate the psycholinguistic abilities of children with Williams syndrome (WS) and typically developing children using the Illinois Test of Psycholinguistic Abilities (ITPA). Performance on the ITPA was analysed in a group with WS (N=20, mean age=8.5 years, SD=1.62) and two typically developing groups, matched in mental (MA, N=20, mean age=4.92 years, SD=1...

Feedback is one of the most influential factor when it comes to learning success of students. Especially large-scale classes at universities often lack feedback caused by the scarcity of resources. Even though a lack of feedback is problematic across all domains, especially when educating future IS executives, who are supposed to lead team members by providing effective feedback. In this study,...