Using a quantitative technic for depositing a definite number of carcinoma or sarcoma cells into the anterior chamber of the mouse eye, without leakage as proven by complete reten tion of Trypan blue dye, this route generally required a 100to 1,000-fold lower dose of cells to produce tumors in 100% of animals, as compared to the intramuscular, intravenous, and intraperitoneal routes of inoculat...

A temperature-sensitive (ts) mutant, tsG1, has been isolated from the CVS (Challenge Virus Standard) strain of rabies virus. The ts mutation affects the glycoprotein (G protein); it consists of an amino acid substitution (leucine to phenylalanine) at position 132. tsG1 exhibits a slightly reduced pathogenicity when administered via the intracerebral route and complete avirulence after intramusc...

Using a quantitative technic for depositing a definite number of carcinoma or sarcoma cells into the anterior chamber of the mouse eye, without leakage as proven by complete reten tion of Trypan blue dye, this route generally required a 100to 1,000-fold lower dose of cells to produce tumors in 100% of animals, as compared to the intramuscular, intravenous, and intraperitoneal routes of inoculat...

A lytic bacteriophage, which was previously isolated from sewage and which attaches to the K1 capsular antigen, has been used to prevent septicemia and a meningitis-like infection in chickens caused by a K1+ bacteremic strain of Escherichia coli. Protection was obtained even when administration of the phage was delayed until signs of disease appeared. The phage was able to multiply in the blood...

PURPOSE New alternative bait rabies vaccines applicable to pet dogs and wild animals are needed to eradicate rabies in Korea. In this study, recombinant rabies virus, ERAG3G strain was constructed using reverse genetic system and the safety, efficacy and immunogenicity of the ERAG3G strain was evaluated in mice and dogs. MATERIALS AND METHODS Using the full-length genome mutated amino acid at...

We previously found that tonsillar application of antigen induces a strong antibody response to Streptococcus sobrinus in saliva and blood plasma. Rabbits immunized against S. sobrinus by tonsillar application were highly resistant to experimental dental caries triggered by oral inoculation of living S. sobrinus organisms with sucrose. In the present study, we examined the reaction of S. sobrin...

We report a case of an intramuscular lipoma with the following karyotype: 46,XY,t(12;14) (q14–15;q24). To our knowledge, this is the third report of a t(12;14) as a sole abnormality in a lipoma. © Elsevier Science Inc., 1998

To better understand the mechanisms by which neurotropic viruses invade peripheral nerve pathways and produce CNS disease, we defined the type 3 (T3) reovirus genes that are determinants of the capacity of reovirus T3 strain Dearing (T3D) and T3 clone 9 (C9) to infect the spinal cord and kill mice after hindlimb injection. T3D and C9 viruses are both highly virulent (LD(50) < 10(1) PFU) after i...