نتایج جستجو برای: intensive insulin therapy

تعداد نتایج: 934970  

Journal: :CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2006
Greet Van den Berghe Dieter Mesotten Ilse Vanhorebeek

Several studies have shown that elevated glucose concentrations in patients with acute coronary syndrome and other acute severe illnesses are associated with increased short- and long-term all-cause and cardiovascular mortality (CVM). This has subsequently led to the use of intensive insulin therapy (IIT) to control hyperglycemia. Earlier studies have shown that the prevention of hyperglycemia ...

2015
Hideaki Jinnouchi Seigo Sugiyama Akira Yoshida Kunio Hieshima Noboru Kurinami Tomoko Suzuki Fumio Miyamoto Keizo Kajiwara Kunihiko Matsui Tomio Jinnouchi

AIMS Glucagon-like peptide-1 (GLP-1) analog promotes insulin secretion by acting on pancreatic β-cells. This antihyperglycemic treatment for type 2 diabetes mellitus (DM) has attracted increased clinical attention not only for its antihyperglycemic action but also for its potential extrapancreatic effects. We investigated whether liraglutide, a GLP-1 analog, could enhance insulin sensitivity as...

Journal: :Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2006
Neil R Orford

The use of intensive insulin therapy (IIT) to maintain blood glucose level below 8.3 mmol/L is recommended for management of severe sepsis by the Surviving Sepsis guidelines. The recent trials reporting reduced morbidity and mortality in critically ill patients treated with IIT require careful examination, including the subsequent post-hoc analyses. An understanding of the molecular and metabol...

2005
Anne Phillips

standards an expert group needs to be established to instigate their initiation and implementation. It becomes essential to examine the beliefs and values underpinning these standards and to ask whether they cohere with clinical practice. Within our own clinical area, it is particularly pertinent that an agreed understanding is met regarding treatment. This has clearly been shown during the rec...

Journal: :The Journal of clinical investigation 2005
Lies Langouche Ilse Vanhorebeek Dirk Vlasselaers Sarah Vander Perre Pieter J Wouters Kristin Skogstrand Troels K Hansen Greet Van den Berghe

The vascular endothelium controls vasomotor tone and microvascular flow and regulates trafficking of nutrients and biologically active molecules. When endothelial activation is excessive, compromised microcirculation and subsequent cellular hypoxia contribute to the risk of organ failure. We hypothesized that strict blood glucose control with insulin during critical illness protects the endothe...

Journal: :Critical care nurse 2011
Andrew C Faust Rebecca L Attridge Laurajo Ryan

Hyperglycemia, a common finding in critically ill patients, is linked to poor outcomes in multiple conditions. The Leuven I study published in 2001 was the first evaluation of intensive insulin therapy, and the 3.4% absolute reduction in mortality in a single-center surgical intensive care unit led to widespread endorsement of the therapy. In a subsequent study in a medical intensive care unit,...

Journal: :Annals of internal medicine 2011
Amir Qaseem Linda L Humphrey Roger Chou Vincenza Snow Paul Shekelle

DESCRIPTION The American College of Physicians (ACP) developed this guideline to present the evidence for the link between the use of intensive insulin therapy to achieve different glycemic targets and health outcomes in hospitalized patients with or without diabetes mellitus. METHODS Published literature on this topic was identified by using MEDLINE and the Cochrane Library. Additional artic...

Journal: :American journal of respiratory and critical care medicine 2005
Derek C Angus Edward Abraham

TheAASM, ATS, andACCP agree that there is an enormous need for research to improve the understanding and treatment of sleep disorders. Thus, the three societies strongly advocate for increased research support in this critical area. In addition, the societies support initiatives to enhance the number of wellqualified researchers in the broad area of sleep medicine. The societies have agreed to ...

Journal: :The New England journal of medicine 2008
Frank M Brunkhorst Christoph Engel Frank Bloos Andreas Meier-Hellmann Max Ragaller Norbert Weiler Onnen Moerer Matthias Gruendling Michael Oppert Stefan Grond Derk Olthoff Ulrich Jaschinski Stefan John Rolf Rossaint Tobias Welte Martin Schaefer Peter Kern Evelyn Kuhnt Michael Kiehntopf Christiane Hartog Charles Natanson Markus Loeffler Konrad Reinhart

BACKGROUND The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. METHODS In a multicenter, two-by-two factorial trial, we randomly assigned patients with severe sepsis to receive either intensive insulin therapy ...

Journal: :The Israel Medical Association journal : IMAJ 2007
Raymond Farah Alexander Samokhvalov Fabio Zviebel Nicola Makhoul

BACKGROUND Hyperglycemia is common among patients admitted to intensive care units, and carries the risk for complications and prolonged ICU stay. With intensive insulin control of blood glucose, morbidity and mortality can be reduced. OBJECTIVES To determine whether intensive or conventional insulin control of blood glucose in hyperglycemic ICU patients correlated with the prognosis. METHO...

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