In this study, the hematological and growth performance of beluga (Huso huso) fed with herbal supplemented diet were studied. Dietary treatments were control (normal diet), 1 g garlic(Allium sativum)and 1 g nettle (Urticadioica) per 100g feed for 60 days. No significant difference was observed in growth performance between the groups(P>0.05). MCV increased significantly in nettle group c...

CD47-deficient hepatocyte transplantation induces rapid innate immune cell activation and subsequent associated graft loss in syngeneic recipients. However, the role of donor CD47 in regulation of T-cell alloresponses is poorly understood. We addressed this question by assessing OVA-specific immune responses in mice following hepatocyte transplantation from CD47-competent or -deficient OVA-tran...

Objectives: To induce immune tolerance in immune-competent animals with a plasmid (p4F10-eB7) expressing a membranebound single-chain antibody against CTLA4. Materials and Methods: Twenty 9-week old immune-competent C57B/L6 mice were divided into 2 groups. Ten mice received an intramuscular injection of 50 μL of endotoxin-free pCBLacZ plasmid at a concentration of 1 mg/mL in phosphate buffer in...

Although animals, in particular mice, are used extensively for skin models, misleading conclusions can be made due to very clear differences between human and animal immunology as illustrated by the fact that extensive differences have been reported between human and mouse DC subsets (Shortman and Liu, 2002;van de Ven et al., 2011). Importantly, no suitable animal models exist to study oral imm...

The human reovirus is an oncolytic virus that specifically targets cancer cells with an activated Ras pathway. Because it is replication competent and highly specific for cancer cells, this virus has the potential to be an effective antimetastatic cancer agent through remote site delivery. In this study, we exploited the ability of reovirus to replicate in murine cells to test the efficacy of t...

BACKGROUND Infectious diseases of the airways are a major health care problem world wide. New treatment strategies focus on employing the body's immune system to enhance its protective capacities during airway disease. One source for immune-competent cells is the pleural space, however, its immune-physiological function remains poorly understood. The aim of this study was to develop an experime...

L-743,872 is a broad-spectrum pneumocandin antifungal drug developed by Merck Research Co., and in the present work it was evaluated in vivo in murine models of Candida krusei and Candida glabrata infection. Mice were infected intravenously with two isolates of C. krusei and treated with fluconazole or L-743,872. Fluconazole was beneficial only in immune-competent mice infected with isolate 94-...