Background: Diabetes mellitus type 2 with dyslipidemia is a common disease. Previous studies suggest that chemical constituent present in pinus eldarica (P. eldarica) nut posesess antioxidant properties and positively affect glucose metabolism. However blood glucose and cholesterol lowering effects of P. eldarica nut have not been studied so far. Objective: The present study was undertaken to e...

OBJECTIVE C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis. Mouse CRP is not expressed at high levels under normal conditions and increases in concentration only several-fold during an acute phase response. Because the dynamic range of human CRP is much larger, apolipoprotein ...

Objectives: There is evidence that the antioxidant systems are imbalanced in hypercholesterolemic rats due to oxidative stress. Dietary supplementation of Pleurotus sajor-caju and P. florida are anti-hypercholesterolemic in rats. In this study, it was investigated whether these mushrooms have any effects on the antioxidant systems in hypercholesterolemic rat liver, which are altered. Methods: T...

Hypercholesterolemia impairs endothelium-dependent relaxations to several platelet-derived substances in large vessels. The effect of hypercholesterolemia on the response of coronary microvessels to platelet products and thrombin is less well defined. Three groups of cynomolgus monkeys were studied: normal (n = 6), short-term hypercholesterolemic (8-11 weeks, n = 5), and long-term hypercholeste...

OBJECTIVE We sought to assess the activity of endogenous endothelin-1 (ET-1) in hypercholesterolemic patients using antagonists of ET-1 receptors. BACKGROUND Endothelial dysfunction in hypercholesterolemic patients may contribute to their risk of premature atherosclerosis. Endothelin, a peptide released by endothelial cells, may be involved in this process by activating smooth muscle cell mit...

BACKGROUND Hypercholesterolemia is a condition characterised with high level of cholesterol in the blood. OBJECTIVES The effect of ethanolic extract of Buchholzia coriacea (EEBC) on the lipid profile levels and extent of lipid peroxidation in hypercholesterolemic albino rats was investigated in this study. METHODS Thirty albino rats were divided into six different groups which consist of gr...

background: this study was performed to effects of garlic and lemon juice mixture on lipid profile and some cardiovascular risk factors in people 30–60 years old with moderate hyperlipidemia. methods: in a parallel‑designed randomized controlled clinical trial, a total of 112 hyperlipidemic patients 30–60 years, were recruited from isfahan cardiovascular research center. people were selected an...

The purpose of this study was to determine whether the free cholesterol of hypercholesterolemic low density lipoprotein from cholesterol-fed nonhuman primates has a greater potential for surface transfer to cell membranes than does the free cholesterol of normal low density lipoprotein. The low density lipoproteins were isolated from normal and hypercholesterolemic rhesus and cynomolgus monkeys...