Comment This study showed an unexpectedly high rate (10%) of allergic contact dermatitis to transdermal hyoscine in healthy men treated for several months. Allergic contact dermatitis (type IV delayed hypersensitivity) was diagnosed by well established clinical criteria and was further confirmed by the absence ofany reaction to a placebo patch. Our results contrast with those of studies conduct...

The safety index of ether, chloroform and halothane in mice has been determined after administration of each of seven combinations of drugs commonly used in pre-anaesthetic medication. Following hyoscine-morphine and pentobarbitone-atropine the index for ether was significantly higher than that of the control series, whilst following atropine-pethidine it was significantly lower. The index for ...

Sir,—Koski and colleagues [1] found no difference in the incidence of nausea and vomiting in patients receiving transdennal hyoscine or placebo before operation. This is at variance with the findings of others [2]. A number of points warrant mention. In the study of Koski, different types of surgery were performed, whereas only patients having gynaecological surgery were studied by Uppington, D...

Using Ridit analysis, a comparison was made of the overall effects of what are generally considered to be equianalgesic doses of sixteen opiates, with respect to their desired and toxic effects when given as premedication to a standard population. Four mixtures of opiates, the non-opiate diazepam and saline were also included in the analysis. Results with all individual drugs have been previous...

Datura metal L is an important medicinal plant containing the alkaloids like scopalamine(hyoscine),hyoscyamine(atropine) scutellaerin etc .The total alkaloids present in the callus were higher than the amount of alkaloids present in leaves .For the higher production of alkaloids the medium plays avital role.The addition of L-arginine were enhanced the alkaloid production The higher production o...

Hyoscine N-butyl bromide, also known as scopolamine, is a type of antimuscarinic agent. This drug is associated with numerous common side effects, including abdominal fullness, constipation, urinary retention, blurred vision, skin flushing, tachycardia, decreased sweating, and salivation. The most unfavorable side effect is hemodynamic instability. In the present case, hypotension and acute myo...

Objective: Hyoscine-N-butylbromide is used by some surgeons during laparoscopic sleeve gastrectomy (LSG) to loosen gastric smooth muscles and provide a more effective LSG. However, evidence-based data on the effects of hyoscine-N-butylbromide in are limited its effect surgery weight loss unknown. The aim this study was analyze intraoperatively administered stomach resection volume, complication...