The present study was designed to investigate the function and mechanism of high-frequency stimulation (HFS) of the parafascicular nucleus (PF) used as a therapeutic approach for Parkinson's disease (PD). PD rat model was built by injecting 6-hydroxydopamine (6-OHDA) into the substartia nigra pars compacta of adult male Sprague-Dawley rats. Using the ethological methods, we examined the effect ...

Background: Previous studies have shown cycloserine to be neuroprotective in some neurodegenerative disorders. Objectives: To investigate the effect of cycloserine on motor function in Parkinson’s disease in a rat model. Materials and Methods: Fifty-six healthy male wistar rats were used in this study and were divided into seven groups according to receiving saline, low dose (i.e. 100 m...

Nowadays, piezoelectric materials have wide applications in various industries. Therefore, investigation of these materials and their applications has a special importance. In this paper first, the natural frequencies of a traveling-wave piezoelectric motor are achieved, using finite elements simulations. Then, applying an alternative electrical voltage to the piezoelectric ring, a traveling wa...

objective: there is longstanding experimental and clinical evidence that supports the idea that replacement of dopaminergic (daergic) neurons can ameliorate functional disabilities of parkinson’s disease (pd). the purpose of the present study is to examine the efficacy of transplantation of rat bone marrow stromal cell (bmscs)-derived tyrosine hydroxylase-positive (th+) cells induced by depreny...

Effects of radio-frequency lesions or injections of 6-hydroxydopamine (6-OHDA) into far-lateral hypothalamus (FLH) and substantia nigra (SN) on feeding behavior and motor activity were studied in four groups of cats. Hypoactivity, aphagia and adipsia followed by gradual recovery of alimentary behavior were observed only after radio- frequency lesions of FLH (group I). 6-OHDA injections into FLH...

The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying motor and limbic functions. Multiple reports suggest that these processes are influenced by hemispheric differences in striatal dopamine (DA) levels, DA turnover and its receptor activity. Here, we review studies which measured the concentration...

Parkinson’s disease (PD) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (SN) in midbrain due to loss dopaminergic neurons. Emerging studies revealed promising effects some nutrient compounds reducing risk PD. One such compound that possess neuroprotective and prevents neurodegeneration tocotrienol (T3), vitami...

1. The rat anococcygeus muscle possesses a dense motor adrenergic innervation and also a powerful inhibitory innervation whose transmitter is unknown. The possibility that the adrenergic nerves released both noradrenaline and the unknown inhibitory transmitter was investigated by destroying the adrenergic nerves either by immunosympathectomy or by 6-hydroxydopamine.2. Immunosympathectomy was on...

Theaflavins, the oxidation products of tea polyphenols are important biologically active components of black tea. 6-hydroxydopamine is a pro-parkinsonian neurotoxin. Theaflavins could inhibit the auto-oxidation of 6-hydroxydopamine in a dose-dependent manner from 0.5 µg/ml to 25 µg/ml. Here we investigated the protective effect of theaflavins on 6-hydroxydopamine induced SH-SY5Y cells against a...